Transposons: crossroads, crosstalk and gene regulation

By: James V. Kohl | Published on: March 5, 2020
Transposons: crossroads, crosstalk and gene regulation(click to enlarge)

The energy-dependent space-time continuum links Creation of the sense of smell in bacteria to our visual perception of energy and mass via Olfaction Warps Visual Time Perception. That fact may require National Parks to revise their claims about evolution across billions to millions of years.

See:

At 10:22, the claim is stated that:

…shallow valleys of limestone that have been eroded over the past 5000 years

That claim links the middens of the earliest inhabitants, about 4,500 years ago, to what is known about the energy-dependent physiology of reproduction in Geobacter and to sympatric speciaton in periphyton.

For comparison to across-kingdom sympatric speciation from Geobacter to periphyton, you can see how shotgun genomics was used to misrepresent the age of pack-rat ecosystems via their middens. Theorists theorists claim the middens are from 300 to 48,000 years old in Paleo‐metagenomics of North American fossil packrat middens: Past biodiversity revealed by ancient DNA 2/20/20
Warning: Some paleoecologists link C14 dating to claims about paleo-metagenomics and the age of  middens by starting with claims from other biologically uninformed theorists. The theorists tend to start with ancient DNA. Their claims can be compared to the claims of serious scientists who have linked God’s Creation of sunlight and water to oxygen-dependent biophysically constrained viral latency via light-activated carbon fixation and RNA interference.
For instance, the patent for naturally occurring light-activated carbon fixation and RNA interference links biophysically constrained viral latency to healthy ecosystems in all living genera.
See: RNA-Guided Human Genome Engineering

5. Repetitive elements or endogenous viral elements can be targeted with engineered Cas+gRNA systems in microbes, plants, animals, or human cells to reduce deleterious transposition or to aid in sequencing or other analytic genomic/transcriptomic/proteomic/diagnostic tools (in which nearly identical copies can be problematic).

See for contrast: Crossroads between transposons and gene regulation

Transposons are mobile genetic elements that have made a large contribution to genome evolution in a largely species-specific manner. A wide variety of different transposons have invaded genomes throughout evolution…

The assumption that invaded genomes evolve has never been supported by experimental evidence of top-down causation. Top-down causation is energy-dependent and microRNA-mediated via light-activated carbon fixation, which biophysically constrains RNA interference.

See: Transposable elements as a potent source of diverse cis-regulatory sequences in mammalian genomes

Eukaryotic gene regulation is mediated by cis-regulatory elements, which are embedded within the vast non-coding genomic space and recognized by the transcription factors in a sequence- and context-dependent manner.

Gene regulation is energy-dependent and energy is linked to their claim about the context-dependent manner.

See: An atlas of transposable element-derived alternative splicing in cancer

Transposable element (TE)-derived sequences comprise more than half of the human genome, and their presence has been documented to alter gene expression in a number of different ways, including the generation of alternatively spliced transcript…

Energy is required for the generation of alternatively spliced transcripts. The senior author, I. King Jordan should know that. No serious scientists took his claims seriously when he wrote: Amino acid composition of proteins varies substantially between taxa and, thus, can evolve.
Similarly, genomic responses do not evolve. See: Transposable elements contribute to the genomic response to insecticides in Drosophila melanogaster

Most of the genotype–phenotype analyses to date have largely centred attention on single nucleotide polymorphisms. However, transposable element (TE) insertions have arisen as a plausible addition to the study of the genotypic–phenotypic link.

The genotypic–phenotypic link is energy-dependent and biophysically constrained by the physiology of reproduction. Everything known about the genotypic–phenotypic link requires the energy-dependent Creation of enzymes.
See: KAP1 targets actively transcribed genomic loci to exert pleomorphic effects on RNA polymerase II activity

KAP1 (KRAB-associated protein 1) is best known as a co-repressor responsible for inducing heterochromatin formation, notably at transposable elements. However, it has also been observed to bind the transcription start site of actively expressed genes

Proteins do not automagically Create themselves and neither do actively expressed genes. What then can be said about theorists who skip the energy-dependent creation of enzymes and make claims about ‘junk’ DNA, evolved species or other neo-Darwinian pseudoscientific nonsense?

See: On transposons and totipotency

Our perception of the role of the previously considered ‘selfish’ or ‘junk’ DNA has been dramatically altered in the past 20 years or so. A large proportion of this non-coding part of mammalian genomes is repetitive in nature…

See also: Arabidopsis RNA Polymerase IV generates 21–22 nucleotide small RNAs that can participate in RNA-directed DNA methylation and may regulate genes

The plant-specific RNA Polymerase IV (Pol IV) transcribes heterochromatic regions, including many transposable elements (TEs), with the well-described role of generating 24 nucleotide (nt) small interfering RNAs (siRNAs). These siRNAs target DNA

Are any neo-Darwinian theorists using the right tools and techniques to elaborate on energy-dependent biophysically constrained gene regulation?
See: Mobile genomics: tools and techniques for tackling transposons

Next-generation sequencing approaches have fundamentally changed the types of questions that can be asked about gene function and regulation. With the goal of approaching truly genome-wide quantifications of all the interaction partners…

All the interaction partners are energy-dependent and microRNA-mediated.

But see: Widespread correlation of KRAB zinc finger protein binding with brain-developmental gene expression patterns

The large family of KRAB zinc finger (KZNF) genes are transcription factors implicated in recognizing and repressing repetitive sequences such as transposable elements (TEs) in our genome. Through successive waves of retrotransposition-mediated…

When did energy-dependent microRNA-mediated gene regulation become retrotransposition-mediated and/or SINE-mediated?

See: Short interspersed nuclear element (SINE)-mediated post-transcriptional effects on human and mouse gene expression: SINE-UP for active duty

This review describes how human cells have used 3′UTR Alu elements to mediate post-transcriptional gene regulation and also describes examples of convergent evolution between human and mouse 3′UTR SINEs.

The review fails to link energy-dependent changes in the microRNA/messenger RNA balance to biophysically constrained viral latency via the mouse-to-human model of EDAR V370A fixation. To her credit, Lynne E. Maquat claims that rodent-specific B and ID (B/ID) SINEs are non-autonomous, which suggests the short interspersed nuclear element (SINE)-mediated post-transcriptional effects on human and mouse gene expression are energy-dependent in all living genera.
All claims about convergent evolution between humans and mice can be reexamined in the context of: Insertion of 60 homing guide RNA (hgRNA) loci in locations scattered throughout the genome.
See: Genetic Alterations
Note: The mouse strain used for this research project, STOCK MARC1-PB7/Mmucd, RRID:MMRRC_065424-UCD, was obtained from the Mutant Mouse Resource and Research Center (MMRRC) at University of California at Davis, an NIH-funded strain repository, and was donated to the MMRRC by George M. Church, Ph.D., Harvard Medical School and Reza Kalhor, Ph.D., Harvard Medical School.

This mouse line is called “Mouse For Actively Recording Cells!” or MARC1. It is used for barcoding and lineage tracing applications in the mouse, as described in the referenced publications. The line does not have a disease phenotype. However, when a MARC1-PB7 mouse is crossed to mice expressing cas9 universally or in a lineage-specific manner, combinatorial and cumulative barcoding starts in the progeny during their development, leading to developmentally barcoded animals that can be used for a multitude of applications, including lineage tracing.

That facts ab0ut lineage tracing are consistent with what is known to serious scientists about the energy-dependent links to the regulation of bacterial infections.
See: Transposable elements have contributed human regulatory regions that are activated upon bacterial infection

Transposable elements (TEs) are increasingly recognized as important contributors to mammalian regulatory systems. For instance, they have been shown to play a role in the human interferon response…

See also: Mutual Regulation of RNA Silencing and the IFN Response as an Antiviral Defense System in Mammalian Cells 2/17/20

RNA silencing is a posttranscriptional gene silencing mechanism directed by endogenous small non-coding RNAs called microRNAs (miRNAs). By contrast, the type-I interferon (IFN) response is an innate immune response induced by exogenous RNAs, such as viral RNAs. Endogenous and exogenous RNAs have typical structural features and are recognized accurately by specific RNA-binding proteins in each pathway. In mammalian cells, both RNA silencing and the IFN response are induced by double-stranded RNAs (dsRNAs) in the cytoplasm, but have long been considered two independent pathways. However, recent reports have shed light on crosstalk between the two pathways, which are mutually regulated by protein-protein interactions triggered by viral infection. This review provides brief overviews of RNA silencing and the IFN response and an outline of the molecular mechanism of their crosstalk and its biological implications. Crosstalk between RNA silencing and the IFN response may reveal a novel antiviral defense system that is regulated by miRNAs in mammalian cells.

Theorists tend to skip the facts about the crosstalk between the two pathways and skip the facts about energy-dependent microRNA-mediated biophysically contrained viral latency.
See: Human transposon insertion profiling by sequencing (TIPseq) to map LINE-1 insertions in single cells

Long interspersed element-1 (LINE-1, L1) sequences, which comprise about 17% of human genome, are the product of one of the most active types of mobile DNAs in modern humans. LINE-1 insertion alleles can cause inherited and de novo genetic diseases

Claims about inherited and de novo genetic diseases elicit ridicule from serious scientists who know that supercoiled DNA does not create itself.
See: Structural diversity of supercoiled DNA

Six decades after the elucidation of its double helical structure, DNA continues to surprise us by revealing new information. Our cryo-ET, biochemical, and computational studies show the astounding versatility and dynamism of DNA depending on the degree of supercoiling.

See for comparison: Contribution of unfixed transposable element insertions to human regulatory variation

Thousands of unfixed transposable element (TE) insertions segregate in the human population, but little is known about their impact on genome function. Recently, a few studies associated unfixed TE insertions to mRNA levels of adjacent genes…

The levels of biological organization linked to mRNA levels of adjacent genes link the pheromone-controlled physiology of reproduction in soil bacteria to biophysically contrained RNA interference in plants and mammals.

See:Construction and characterization of a knock-down RNA interference line of OsNRPD1 in rice (Oryza sativa ssp japonica cv Nipponbare)

In plants, RNA-directed DNA methylation (RdDM) is a silencing mechanism relying on the production of 24-nt small interfering RNAs (siRNAs) by RNA POLYMERASE IV (Pol IV) to trigger methylation and inactivation of transposable elements (TEs).

See also:sRNA/L1 retrotransposition: using siRNAs and miRNAs to expand the applications of the cell culture-based LINE-1 retrotransposition assay

L1 activity has generated at least a third of the human genome during evolution, and RC- L1s, Alus and SVAs continue to impact our genome.

The links from RNA interference to biophysically constrained viral latency and all biodiversity can also be placed into the context of what theorists call virus evolution.

Substitutions Near the Receptor Binding Site Determine Major Antigenic Change During Influenza Virus Evolution

 Koel et al. (p. 976) show that major antigenic change can be caused by single amino acid substitutions.

The single amino acid substitutions link ecological variation to ecological adaptations via changes in enzymes that cause changes in the microRNA/messenger RNA balance.
See for an example of how the changes are linked to adaptations in neurons:
Hypoxia-induced apoptosis of Astrocytes is mediated by reduction of Dicer and activation of caspase-1 3/4/20

 

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0
Sex differences: Liberals vs Conservatives (1)
4 MIN READ
0
Trans-kingdom RNA interactions (1)
2 MIN READ
0
Nutrient-dependent Pheromone-controlled cures (2)
4 MIN READ
0
Lewis Thomas (revisited): 90K (7)
3 MIN READ
0
The tipping point (revisited) 90K (4)
4 MIN READ
0
Sunlight, hydrophobicity and biodiversity (3)
5 MIN READ
0
Bastardized health care (5)
4 MIN READ
0
Bastardized health care (4)
4 MIN READ
0
Weaponized health information (8)
6 MIN READ
0
Weaponized Health Communication (1)
3 MIN READ
0
The tipping point (revisited): 89K (5)
4 MIN READ
0
The tipping point (revisited): 89K (4)
3 MIN READ
0
The tipping point (revisited): 89K (2)
2 MIN READ
0
Genetic endemism: apologetics vs epigenetics (2)
3 MIN READ
0
Genetic endemism: apologetics vs epigenetics (1)
2 MIN READ
0
Relatable not debatable (2)
2 MIN READ
0
Light-altered chirality and microRNA biogenesis (1)
4 MIN READ
0
MicroRNA-mediated enhancer-promoter chemistry
6 MIN READ
0
pH, amino acids, and health: Effects of sunlight and well wishes
2 MIN READ
0
Anthony S. Fauci refutes theistic evolution
3 MIN READ
0
The tipping point (revisited): 87K (3)
4 MIN READ
0
The tipping point (revisited): 87K (1)
6 MIN READ
0
The tipping point (revisited): SETD2
3 MIN READ
0
Ecological Adaptations: From Angstroms to Ecosystems (2)
3 MIN READ
0
Light and life-sucking black holes (3)
5 MIN READ
0
Kohl and Francoeur at 25 (8)
2 MIN READ
0
Light and life-sucking black holes (2)
2 MIN READ
0
Olfaction and microRNA signaling constrain longevity (3)
< 1 MIN READ
0
Olfaction and microRNA signaling constrain longevity (2)
2 MIN READ
0
The tipping point (revisited): 85,000 publications
4 MIN READ
0
Kohl and Francoeur at 25 (3)
3 MIN READ
0
Combating ignorance to fight disease (1)
4 MIN READ
0
Biophysical constraints on RNA synthesis (1)
9 MIN READ
0
Virus-driven downsizing of the human brain (5)
5 MIN READ
0
Preprints obfuscate facts (2)
4 MIN READ
0
RNA processing and disease (3)
3 MIN READ
0
Ecological adaptation vs neo-Darwinian nonsense (4)
2 MIN READ
0
Ecological adaptation vs neo-Darwinian nonsense (1)
2 MIN READ
0
Darwin Day 2019 (4) #darwinday2019
3 MIN READ
0
Darwin Day 2019 (3) #darwinday2019
3 MIN READ
0
Blood music orchestrates human life (3)
3 MIN READ
0
Do not call me Ishmael (3)
3 MIN READ
0
Do not call me Ishmael (1)
3 MIN READ
0
10,000 reasons to believe in biophysical constraints (revisited)
< 1 MIN READ
0
Phytoremediation, Microbiome and CRISPR (4)
4 MIN READ
0
Phytoremediation, Microbiome and CRISPR (3)
5 MIN READ
0
Autophagy automagically prevents cancer (2)
2 MIN READ
0
Phytoremediation, Microbiome and CRISPR (1)
3 MIN READ
0
Light-activated constrained biodiversity (2)
4 MIN READ
0
Light-activated constrained biodiversity
7 MIN READ
0
Light-activated carbon fixation (2)
3 MIN READ
0
Light-activated carbon fixation (1)
2 MIN READ
0
The tipping point (revisited): 82,000 publications (5)
3 MIN READ
0
The tipping point (revisited): 82,000 publications (1)
3 MIN READ
0
The tipping point (revisited): 82,000 publications (3)
2 MIN READ
0
Viral latency vs deadly paleoanthropology (1)
4 MIN READ
0
Light and life at base pair resolution (10)
4 MIN READ
0
Plant microRNAs regulate across-kingdom gene expression (1)
2 MIN READ
0
Science journalism: a threat to humanity (1)
3 MIN READ
0
The tipping point (revisited): 81,000 publications (5)
2 MIN READ
0
The tipping point (revisited): 81,000 publications (1)
5 MIN READ
0
From microRNA.pro to quantumsouls.pro (3)
5 MIN READ
0
Hide and seek with science facts (8)
2 MIN READ
0
Hide and seek with science facts (7)
3 MIN READ
0
Hide and seek with science facts (3)
2 MIN READ
0
The perfect symmetry of nature
2 MIN READ
0
Darwin’s Children (2003) and Denton’s Children of the Light (2)
5 MIN READ
0
North Korea quietly thanks God that Trump is a Creationist (2)
3 MIN READ
0
Happy Veteran’s Day 2018 (2)
4 MIN READ
0
I can’t fix stupid (1)
< 1 MIN READ
0
SfN’s 2018 trap set for Democrats
2 MIN READ
0
Evolved suffering and death caused by statistical significance
< 1 MIN READ
0
CDC vs WHO (2): Adaptive regulatory variation
6 MIN READ
0
MicroRNA biogenesis protects us from HERVs (3)
5 MIN READ
0
CDC vs Who?
5 MIN READ
0
War Games: False Flag Terrorism (4)
3 MIN READ
0
Creating an enzyme that kills theories (1)
< 1 MIN READ
0
Using gobbledygook to frighten people
4 MIN READ
0
Biologos bastardized it all, again
3 MIN READ
0
Copying Nature’s Design Process (3)
2 MIN READ
0
Are Kavanaugh’s accusers terrorists?
4 MIN READ
0
Energy-dependent enzyme catalysis
4 MIN READ
0
Diagnosis: 120 years of human idiocy
< 1 MIN READ
0
Information Wars started by medical practitioners (1)
< 1 MIN READ
0
Natural models inspire future therapeutics (2)
2 MIN READ
0
Estranged ‘White Coat Notes’ blogger exposes human idiocy (1)
5 MIN READ
0
Predicting naturally occurring viral latency
3 MIN READ
0
Virus-driven genome engineering causes cancer?
2 MIN READ
0
The concept of a species (3)
4 MIN READ
0
The tipping point (revisited): 74,000 publications
4 MIN READ
0
MicroRNA-mediated alternative splicing (revisited)
4 MIN READ
0
Animal welfare vs human ethology
4 MIN READ
0
Biologically uninformed science idiot: Self-defense (1)
3 MIN READ
0
The eternal significance of microRNAs and the Vietnam Memorial (2)
4 MIN READ
0
The eternal significance of microRNAs and the Vietnam Memorial (1)
3 MIN READ
0
From quantum physics to quantum souls (2)
2 MIN READ
0
Epigenetic inheritance of spatiotemporal regulation (5)
8 MIN READ
0
Epigenetic inheritance of spatiotemporal regulation (3)
5 MIN READ
0
The eternal significance of microRNAs (5)
2 MIN READ
0
ATP and RNA-mediated chromosomal stability
3 MIN READ
0
A single base change refutes theistic evolution (2)
2 MIN READ
0
Ecological adaptations vs the randomness of evolution (3)
4 MIN READ
0
A single base change refutes theistic evolution
5 MIN READ
0
EDAR V370A and sympatric speciation
2 MIN READ
0
Virus-driven cystinosis
2 MIN READ
0
Environmental selection is natural selection (5)
5 MIN READ
0
Environmental selection is natural selection (4)
2 MIN READ
0
The poetry of human genome creation
< 1 MIN READ
0
Environmental selection is natural selection
3 MIN READ
0
MicroRNA-mediated denuclearization (6)
2 MIN READ
0
MicroRNA-mediated denuclearization (4)
2 MIN READ
0
Abiogenesis vs microRNA biogenesis (3)
2 MIN READ
0
Abiogenesis vs microRNA biogenesis (2)
7 MIN READ
0
2018 March for Science vs microRNAs (2)
4 MIN READ
0
2018 March for Science vs microRNAs
7 MIN READ
0
The eternal significance of microRNAs (1)
< 1 MIN READ
0
Sympatric Speciation vs pseudosceintific nonsense (4)
2 MIN READ
0
Complexity: Routes and Patterns (4)
< 1 MIN READ
0
Is meat protein unhealthy? (2)
2 MIN READ
0
Is meat protein unhealthy? (1)
< 1 MIN READ
0
Complexity: Routes and Patterns (2)
< 1 MIN READ
0
RNA-mediated nutritional psychiatry (2)
2 MIN READ
0
RNA-mediated nutritional psychiatry
4 MIN READ
0
Polymaths and paradigm shifts: From Asimov to Bear (5)
5 MIN READ
0
Polymaths and paradigm shifts: from Asimov to Bear (1)
5 MIN READ
0
Carl Zimmer refutes theistic evolution (2)
2 MIN READ
0
Ecological adaptation: A new definition of heredity (3)
4 MIN READ
0
Creating biophysically constrained viral latency (2)
2 MIN READ
0
Light-activated carbon fixation did not evolve (4)
7 MIN READ
0
Conceptual critique: Innateness vs the death gene (1)
5 MIN READ
0
How to biophysically constrain the flu virus (1)
4 MIN READ
0
Diet-driven RNA interference and mental health (4)
8 MIN READ
0
Cryo-EM: Linking spatial and conformational constraints
9 MIN READ
0
A reversible TCA cycle in a thermophile (3)
4 MIN READ
0
A reversible TCA cycle in a thermophile
5 MIN READ
0
A mental health problem at the highest level (3)
7 MIN READ
0
Diet-driven RNA interference and mental health (3)
4 MIN READ
0
Anti-entropic sunlight: Schrödinger’s Creationist Secret? (4)
8 MIN READ
0
Anti-entropic sunlight: Schrödinger’s Creationist Secret? (3)
6 MIN READ
1
Anti-entropic sunlight: Schrödinger’s Creationist Secret? (2)
4 MIN READ
0
BiondVax Universal Flu Vaccine Patent
4 MIN READ
0
Diet-driven RNA interference and mental health (2)
3 MIN READ
0
The MicroRNAome Strikes Back: A Sokalian hoax (5)
6 MIN READ
0
The MicroRNAome Strikes Back: A Sokalian hoax (3)
4 MIN READ
0
The MicroRNAome Strikes Back: A Sokalian hoax (2)
6 MIN READ
0
A mental health problem at the highest level (2)
3 MIN READ
0
Diet-driven RNA interference and cancer prevention (3)
6 MIN READ
0
Autophagy is the antiphage defense strategy (2)
4 MIN READ
0
Enzyme-constrained interethnic diversity (8)
< 1 MIN READ
0
Enzyme-constrained interethnic diversity (7)
6 MIN READ
0
Enzyme-constrained interethnic biodiversity (6)
8 MIN READ
0
Enzyme-constrained interethnic biodiversity (1)
5 MIN READ
0
A Mathematical Model Links Quantum Physics to Quantum Souls (2)
4 MIN READ
0
The “walking fish” walks straight from quantum physics to quantum souls (4)
11 MIN READ
0
The “walking fish” walks straight from quantum physics to quantum souls (2)
3 MIN READ
0
The “walking fish” walks straight from quantum physics to quantum souls
6 MIN READ
0
A Mathematical Model Links Quantum Physics to Quantum Souls (1)
6 MIN READ
0
From base editing to RNA editing (6)
8 MIN READ
0
Energy-dependent base editing and correction of mutations (3)
3 MIN READ
0
Darwinian adaptation: a clear evolutionary trail?
4 MIN READ
0
Agilent technology and energy-dependent autophagy
8 MIN READ
0
Narcissistic egomaniacal and deadly denial of autophagy
6 MIN READ
0
The overwhelming ignorance of sex researchers (2)
4 MIN READ
0
Who created your virus-driven death gene? (2)
10 MIN READ
0
Energy-dependent base editing and correction of mutations (2)
9 MIN READ
0
Trashing the 2nd Law
7 MIN READ
0
The overwhelming ignorance of sex researchers
5 MIN READ
0
Two retractions of human idiocy
2 MIN READ
0
Reporting new scientific truths is not allowed in the USA
3 MIN READ
0
Denying Creation via RNA-directed DNA methylation
4 MIN READ
0
MicroRNAs and the Cassandra syndrome (revisited)
4 MIN READ
0
A null mutation and healthy longevity?
4 MIN READ
0
Light-activated error free DNA repair
5 MIN READ
0
Achromobacter and killer theories
2 MIN READ
0
Eutrophication and phosphorylated biodiversity
6 MIN READ
0
The next reformation: 500 years too late? (1)
< 1 MIN READ
0
The next reformation: 500 years too late? (2)
2 MIN READ
0
From base editing to RNA editing (2)
7 MIN READ
0
From base editing to RNA editing
2 MIN READ
0
Cryo-EM: More than a suggestion
< 1 MIN READ
0
Exome Sequencing Impact in Routine Care
4 MIN READ
0
Virulence: Out of stock
2 MIN READ
0
Energy-dependent structure and function: Until death (5)
4 MIN READ
0
Entertaining yourself to death
6 MIN READ
0
Criticisms of a validated model
9 MIN READ
0
Predicting who wins the 2017 Nobel Prizes (2)
4 MIN READ
0
1996-2016: Ignoring alternative splicings of pre-mRNA
7 MIN READ
0
Sci-Hub vs limits on the dissemination of information
6 MIN READ
0
Evolutionary theories of epigenetic drift
2 MIN READ
0
Host-derived creation of all pathology (2 of 2)
9 MIN READ
0
God vs host-derived creation of virus-driven pathology
6 MIN READ
0
Your indifference is killing you and others (4)
4 MIN READ
0
Robert Sapolsky’s legacy of atheistic pseudoscientific nonsense
4 MIN READ
0
Energy-dependent physical and biophysical constraints (10)
8 MIN READ
0
MicroRNAs GnRH and the failure of sex research
7 MIN READ
0
God’s shrinking role in salvation (2)
5 MIN READ
0
MicroRNAs light up life
7 MIN READ
0
From E. coli to monkeys and mankind: Theories vs models (5)
5 MIN READ
0
Food energy-dependent epigenetic adaptation (2)
< 1 MIN READ
0
Energy-dependent epigenetic translation to mRNA stability (6)
8 MIN READ
0
Energy-dependent epigenetic translation to mRNA stability (5)
4 MIN READ
0
UV light and non-coding RNA
2 MIN READ
0
Energy as information and constrained endogenous RNA interference (4)
7 MIN READ
0
What energy source do proteins prefer?
6 MIN READ
0
The Virus-Driven Suicide March for Science
5 MIN READ
0
Viruses in pathogenic variants disrupt alternative splicings (2)
3 MIN READ
0
Respiration-dependent endogenous RNA interference
4 MIN READ
0
Functionally interdependent editing and methylation
4 MIN READ
0
Food for thought: Penrose v Ellis (3)
4 MIN READ
0
Magnussen’s “Faith fools” keep the faith
3 MIN READ
0
The essence of precision medicine
4 MIN READ
0
Allen Institute confirms food energy is information
6 MIN READ
0
RNA-mediated adult learning, memory, and neurogenesis
3 MIN READ
0
Theistic evolutionists fight back and lose
4 MIN READ
0
Bill Gates refutes theistic evolution (sequel)
8 MIN READ
0
Bill Gates refutes theistic evolution
4 MIN READ
0
Wikipedia refutes theistic evolution
4 MIN READ
0
Energy is information. Objections over ruled. You’re fired!
7 MIN READ
0
Happy Darwin Day (2017)
4 MIN READ
0
George Church refutes theistic evolution
5 MIN READ
0
Dobzhansky 1973 and Precision Medicine (2)
5 MIN READ
0
Trump’s appeal to common sense (2)
3 MIN READ
0
Theorists sell hidden energy (2)
4 MIN READ
0
Energy-dependent hydrogen bonds in supercoiled DNA
7 MIN READ
0
Energy-dependent chirality
6 MIN READ
0
Vietnam Veterans and others with glioblastoma
3 MIN READ
0
Energy-dependent sensory maps (1996-2016)
5 MIN READ
0
Energy-dependent alternative splicings 1996 – 2016
12 MIN READ
0
Re-inventing mutation-driven evolution (2)
4 MIN READ
0
Energy-dependent coulombic, autophagic, polycombic healthy longevity
4 MIN READ
0
Energy-dependent purifying selection / autophagy (3)
2 MIN READ
0
Energy-dependent purifying selection / autophagy (6)
3 MIN READ
0
Energy-dependent purifying selection / autophagy
2 MIN READ
0
Epigenetically effected energy-dependent fluorescence
5 MIN READ
0
Epigenetics and autophagy vs mutations and evolution (2)
2 MIN READ
0
Polycombic ecological adaptation as a science, not a theory (2)
12 MIN READ
0
The natural success of RNAi and failed treatment
7 MIN READ
0
Life is energy-dependent task management
3 MIN READ
0
Chromatin: The structure of DNA
6 MIN READ
0
Consciousness is simply food rearranged
2 MIN READ
0
Hydrogen-atom energy in DNA base pairs
6 MIN READ
0
Light energy-dependent active motifs
6 MIN READ
0
Light energy-induced base pair changes (2)
4 MIN READ
0
Light energy-induced base pair changes (1)
6 MIN READ
0
How did the innate immune system evolve?
4 MIN READ
0
The Aquatic Ape: New evidence?
4 MIN READ
0
Plant microRNAs slow virus-driven aging
3 MIN READ
0
Protecting 4 billion people from virus-driven entropy
< 1 MIN READ
0
Lawless evolution: No physics
4 MIN READ
0
Antithetical conclusions (7)
3 MIN READ
0
Antithetical conclusions (4)
3 MIN READ
0
Anthetical conclusions (2)
5 MIN READ
0
RNAi: From magic bullet to billion dollar baby
4 MIN READ
0
GC-rich neo-Darwinian train wreck
5 MIN READ
0
Biophysically constrained cell type differentiation
3 MIN READ
0
From angstroms to ecosystems
7 MIN READ
0
Food supplement or licensed immunostimulant?
6 MIN READ
0
The end of neo-Darwinism
5 MIN READ
0
Biophotonics, glycobiology, quantized biodiversity
4 MIN READ
0
Light ‘drives’ adaptation; nothing ‘drives’ evolution
6 MIN READ
0
Did “Nature” kill Steve Jobs? (3)
10 MIN READ
0
Did “Nature” kill Steve Jobs? (2)
6 MIN READ
0
Did “Nature” kill Steve Jobs?
3 MIN READ
0
Placing boundaries where none exist
< 1 MIN READ
0
MicroRNAs and sexual orientation
8 MIN READ
0
Innate immunity and multiplexing
7 MIN READ
0
RNA methylation (2)
7 MIN READ
0
Masters of deception about nature (2)
7 MIN READ
0
Cracking the Olfactory Code?
5 MIN READ
0
Energy-dependent RNA methylation (9)
2 MIN READ
0
Energy-dependent RNA methylation (7)
7 MIN READ
0
Energy-dependent RNA methylation (6)
9 MIN READ
0
Energy-dependent RNA methylation (5)
3 MIN READ
0
Half truths support theories without facts
4 MIN READ
0
From angstroms to ecosystems and entropy
2 MIN READ
0
Organic Compounds and the Miracle of Smell and Taste
7 MIN READ
0
Ricki Lewis’ Time Machine (2)
6 MIN READ
0
Virus-perturbed alternative splicings
3 MIN READ
0
MicroRNA-mediated RNA epigenetics
2 MIN READ
0
Epigenetic (re)programming of behavior (3)
5 MIN READ
0
RNA-mediated theory killers (4)
9 MIN READ
0
A million dollar paradox?
2 MIN READ
0
A two-faced protein enables RNA-mediated DNA repair (3)
8 MIN READ
0
A two-faced protein enables RNA-mediated DNA repair (2)
4 MIN READ
0
Neo-Darwinism vs the neocortex
4 MIN READ
0
Receptor methylation controls behavior
2 MIN READ
0
eQTLs and ecological adaptation
< 1 MIN READ
0
Preventing genomic entropy
4 MIN READ
0
Protosuns, prebiotic molecules, proteins, and people
4 MIN READ
0
“First” evidence
5 MIN READ
0
Unknown mechanisms and conclusions
2 MIN READ
0
Protein isoforms do not evolve
3 MIN READ
0
Finding odor and taste receptors everywhere
6 MIN READ
0
RNA-mediated silencing of a chromosome
3 MIN READ
0
Amino acid-dependent cell type differentiation
8 MIN READ
0
Nutrient-dependent RNA interference
4 MIN READ
0
MicroRNAs and invasive phenotypes
< 1 MIN READ
0
Viruses and ecologically adapted animals
2 MIN READ
0
Let there be anti-entropic light (1)
11 MIN READ
0
An epigenetic trap (the prequel)
5 MIN READ
0
Dual genomes: exposing the evolution industry
5 MIN READ
0
Epigenetic pharmacology and RNA-mediated transciptional landscapes
3 MIN READ
0
More than a bag of chemicals?
2 MIN READ
0
No understanding of biodiversity
2 MIN READ
0
RNA-mediated cell type differentiation and behavior
3 MIN READ
0
MiRNAs methylation and ecological adaptation sans mutations
2 MIN READ
0
The wrong picture of our evolution
4 MIN READ
0