pH-dependent viral latency (1)
The current pandemic has no parallel…, but the new virus is following rules common to other pathogens.
The so-called “rules” are Darwin’s “conditions of life.”
Pandemics end when human populations ecologically adapt to viruses. See this 2007 report from researchers at the CDC: A Two-Amino Acid Change in the Hemagglutinin of the 1918 Influenza Virus Abolishes Transmission
Re: A better understanding of microclimate change… and the biodiversity crisis…
For the current understanding climate change and biodiversity, see: Spindle-shaped viruses infect marine ammonia-oxidizing thaumarchaea
…viral predation has a profound impact on thaumarchaeal functioning and mortality, thereby regulating global biogeochemical cycles.
Global biogeochemical cycles of protein biosynthesis are biophysically constrained by hydrogen-atom transfer in DNA base pairs in solution.
3) Freeman Dyson (1923–2020)
“Dyson…showed how to derive Feynman’s rules from Dirac’s theory mathematically…” [and] “… proved that quantum mechanics explains the stability of matter.”
Feynman linked food energy to coherently organized biology, which explains the stability of cell types:
Dobzhansky-Muller incompatibilities are food energy-dependent. Pheromones regulate the genetic processes of microRNA-mediated sympatric speciation via fixation of amino acid substitutions, which link RNA interference to biophysically constrained viral latency in species from microbes to humans.
See also: Nutrient-dependent/pheromone-controlled Adaptive Evolution: A Model (6/14/13)
The model from 2013 was extended from physics and chemistry to pH-dependent molecular epigenetics across all levels of biological organization in 2018.
The model of pH-dependent microRNA-mediated ecological adaptations was recapitulated in Optimal Nutritional Status for a Well-Functioning Immune System Is an Important Factor to Protect against Viral Infections (4/23/20)
Rational protein engineering requires a holistic understanding of protein function. Here, we apply deep learning to unlabeled amino-acid sequences to distill the fundamental features of a protein into a statistical representation that is semantically rich and structurally, evolutionarily and biophysically grounded.
Energy-dependent biophysical constraints comparisons between the hecatombic evolution of pathology and the polycombic ecological adaptations that link the patent for naturally occurring light-activated RNA interference.
See: RNA-Guided Human Genome Engineering (2015)
5. Repetitive elements or endogenous viral elements can be targeted with engineered Cas+gRNA systems in microbes, plants, animals, or human cells to reduce deleterious transposition or to aid in sequencing or other analytic genomic/transcriptomic/proteomic/diagnostic tools (in which nearly identical copies can be problematic).
Link biophysically constrained RNA interference to the prevention of all virus-driven pathology via quantum biology.
See: Photoactivated biological processes as quantum measurements (2015)
We outline a framework for describing photoactivated biological reactions as generalized quantum measurements of external fields, for which the biological system takes on the role of a quantum meter.
Here we survey the state of recent discoveries, present viewpoints that suggest that coherence can be used in complex chemical systems, and discuss the role of coherence as a design element in realizing function.
Molecular Mechanics Simulations and Improved Tight-Binding Hamiltonians for Artificial Light Harvesting Systems: Predicting Geometric Distributions, Disorder, and Spectroscopy of Chromophores in a Protein Environment (2018)
We present molecular mechanics and spectroscopic calculations on prototype artificial light harvesting systems consisting of chromophores attached to a tobacco mosaic virus (TMV) protein scaffold.
The largest of these calculations is Si2H6 which is a simulation of 34 electrons in 152 orbitals. We also present some preliminary results for fast deterministic perturbation theory simulations…
For comparison, see: Mutation-driven evolution (6/14/13) and ask a theorist how the mutations are biophysically constrained to prevent the virus-driven degradation of messenger RNA that serious scientists have linked to all virus-driven pathology across kingdoms.