Coherently organized healthy longevity (1)
(click to enlarge)
A large-scale binding and functional map of human RNA-binding proteins [RBPs] 7/29/20
We describe the spectrum of RBP binding throughout the transcriptome and the connections between these interactions and various aspects of RNA biology, including RNA stability, splicing regulation and RNA localization. These data expand the catalogue of functional elements encoded in the human genome by the addition of a large set of elements that function at the RNA level by interacting with RBPs.
Reported as: ENCODE consortium identifies RNA sequences that are involved in regulating gene expression
The human genome contains about 20,000 protein-coding genes, but the coding parts of our genes account for only about 2 percent of the entire genome. For the past two decades, scientists have been trying to find out what the other 98 percent is doing.
A research consortium known as ENCODE (Encyclopedia of DNA Elements) has made significant progress toward that goal, identifying many genome locations that bind to regulatory proteins, helping to control which genes get turned on or off. In a new study that is also part of ENCODE, researchers have now identified many additional sites that code for RNA molecules that are likely to influence gene expression.
All intelligent serious scientists have learned that gene expression is energy-dependent. The ENCODE consortium now reports this fact in the context of energy-dependent RNA-mediated binding to regulatory proteins (RBPs).
They eliminate the foolish ideas of neo-Darwinian theorists who claimed that amino acids evolved and that proteins evolved.
See for instance: A universal trend of amino acid gain and loss in protein evolution 2/10/05
Amino acid composition of proteins varies substantially between taxa and, thus, can evolve.
For comparison, scientific creationists from South Korea, Israel, and Iran have led the way to this microRNA-mediated conclusion about RBPs. They forced neo-Darwinian theorists to live in fear of the consequences for their failure to start with God’s Creation of energy-as-information.
See:
…the RNA team relied on a technique known as eCLIP, which uses ultraviolet light to cross-link RNA molecules with RNA-binding proteins (RBPs) inside cells.
Researchers from all the Abrahamic faiths have linked God’s Creation of UV light from His Creation of water to all oxygen-dependent life on Earth via plant growth and the physiology of reproduction, and what is known about light-activated changes in RNA synthesis.
microRNA USA 19012 results since 2001
microRNA korea 2241 results since 2002
microRNA Israel 986 results since 2003
Transgenic mouse with the herpes simplex virus type 1 latency-associated gene: expression and function of the transgene
microRNA Iran 1752 results since 2008
For a historical perspective on what is now known about light-activated microRNA-mediated energy-dependent RNA synthesis, see: What is Life? (1944)
Indeed, in the case of higher animals we know the kind of orderliness they feed upon well enough, viz. the extremely well-ordered state of matter in more or less complicated organic compounds, which serve them as foodstuffs. After utilizing it they return it in a very much degraded form -not entirely degraded, however, for plants can still make use of it. (These, of course, have their most power supply of ‘negative entropy’ the sunlight.) (pp. 73 and 74)
Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism and a type of “oxidative phosphorylation” (1964)
The synthesis of RNA in isolated thymus nuclei is ATP dependent.
The link from the thymus to immune system function was clear in:
RNAi and RNA-based regulation of immune system function (10/18/05)
RNA editing and RNAi have an inverse relationship and RNA editing has an important role in viral immunity. These observations indicate unique roles for dsRNAs in the mammalian immune system.
The link from God’s Creation of UV light to RNA editing for comparison to RNA interference (RNAi) and immune system function was clear in:
A Quick HYL1-Dependent Reactivation of MicroRNA Production Is Required for a Proper Developmental Response after Extended Periods of Light Deprivation 7/18/18
…plants alter microRNA (miRNA) biogenesis in response to light transition.
Across kingdom connections from the immune system were clear in:
Plant MicroRNAs in Cross-Kingdom Regulation of Gene Expression 7/10/18
The fact that MicroRNAs regulate APOBEC gene expression to reduce mutagenesis was clear on 6/12/17
In this review, we highlight how microRNAs interact with the APOBEC gene family and post-transcriptionally regulate APOBEC gene expression, and we speculate how targeting specific microRNAs may reduce host genome mutagenesis via inactivation of APOBEC deaminases.
See also: Marine periwinkle stress-responsive microRNAs: A potential factor to reflect anoxia and freezing survival adaptations 7/27/20
…conserved miRNAs reflect survival adaptations by marine periwinkles under anoxic or frozen conditions…
A link from marine invertebrates to terrestrial vertebrates was published as:
The western painted turtle genome, a model for the evolution of extreme physiological adaptations in a slowly evolving lineage 3/28/13
The ability of the painted turtle to withstand complete anoxia and partial freezing appears to be associated with common vertebrate gene networks
Do you believe that life evolved from its persistence in marine sediments that are more than 100 million years old to its existence in snails and turtles?
See: Aerobic microbial life persists in oxic marine sediment as old as 101.5 million years 7/28/20
Our results suggest that microbial communities widely distributed in organic-poor abyssal sediment consist mainly of aerobes that retain their metabolic potential under extremely low-energy conditions for up to 101.5 Ma.
If you believe this pseudoscientific nonsense, you are less likely to believe that pathway analysis of miRNA-related stress survival adaptations, such as cell proliferation in snails, was linked to gene expression by seven hepatopancreas miRNAs. The seven microRNAs were critical to distinguish between snails under different stress conditions, which suggests that all studies of nutrient-dependent pheromone-regulated genetic processes have demonstrated that conserved miRNAs reflect survival adaptations.
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Cytosis: Biology Content
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Virulence and your UTI
2 MIN READ
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Life in your UV light-constrained galaxy
5 MIN READ
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Proof: Sunlight is energy as information
< 1 MIN READ
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The essence of precision medicine: drug targets or healthy longevity?
4 MIN READ
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RNA-mediated adult learning, memory, and neurogenesis
3 MIN READ
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Theistic evolutionists fight back and lose (3)
4 MIN READ
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Theistic evolutionists fight back and lose (2)
4 MIN READ
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Young earth creationists refute theistic evolution
3 MIN READ
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Bill Gates refutes theistic evolution (sequel)
8 MIN READ
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Bill Gates refutes theistic evolution
4 MIN READ
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Wikipedia refutes theistic evolution
4 MIN READ
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RNA editing refutes theistic evolution
4 MIN READ
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Serious scientists refute theistic evolution again
3 MIN READ
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May the anti-entropic force of sunlight be with you
4 MIN READ
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Francis S. Collins refutes theistic evolution
6 MIN READ
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Energy is information. Objections over ruled. You’re fired!
7 MIN READ
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Happy Darwin Day (2017)
4 MIN READ
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George Church refutes theistic evolution (2)
2 MIN READ
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George Church refutes theistic evolution
5 MIN READ
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Mitochondria do not adapt
2 MIN READ
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Energy as information and constrained endogenous RNA interference (2)
2 MIN READ
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Dobzhansky 1973 and precision medicine (3)
5 MIN READ
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Atomic theory vs facts about hydrogen-atom transfer
4 MIN READ
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Twisted theories and weaponized facts
3 MIN READ
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Mutations: the “driving force” behind human brain complexity?
6 MIN READ
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Mutations: the "driving force" behind human brain complexity?
6 MIN READ
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Science journalists or paid propagandists? (2)
3 MIN READ
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Critical values expose virus-driven energy theft (2)
4 MIN READ
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Critical values expose virus-driven energy theft
6 MIN READ
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Energy-dependent chirality
6 MIN READ
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Energy-dependent alternative splicings 1996 – 2016
12 MIN READ
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Energy-dependent oscillating gene networks organize life
4 MIN READ
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Re-inventing mutation-driven evolution (2)
4 MIN READ
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Bio-functional information
3 MIN READ
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Explorers who do not know what is known (2)
6 MIN READ
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Autophagy is the antiphage defense strategy
3 MIN READ
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Tasting light links energy from creation to adaptation
9 MIN READ
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Metabolic Phenotyping Research
2 MIN READ
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Phylogenetic similarity sans energy
2 MIN READ
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Light, behavior and autophagy, a gender-specific risk factor
4 MIN READ
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Controlled amino acid treatment of all pathology
4 MIN READ
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Energy-dependent purifying selection / autophagy (6)
3 MIN READ
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Virus-driven mutation or amino acid substitution
5 MIN READ
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Epigenetically effected energy-dependent fluorescence (2)
6 MIN READ
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Epigenetics and autophagy vs mutations and evolution (5)
2 MIN READ
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From Precis to Proof in 6000 years (3)
2 MIN READ
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From Precis to Proof in 6000 years (2)
5 MIN READ
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From Precis to Proof in 6000 years
9 MIN READ
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Polycombic ecological adaptation as a science, not a theory
3 MIN READ
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The natural success of RNAi and failed treatment
7 MIN READ
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Did evolution autophosphorylate your kinases? (2)
5 MIN READ
1
Hypothesis free pseudoscience vs facts (5)
6 MIN READ
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Chromatin: The structure of DNA (2)
8 MIN READ
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Chromatin: The structure of DNA (3)
4 MIN READ
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DNA repair via junk DNA (2)
5 MIN READ
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Light energy-dependent active motifs
6 MIN READ
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Displays of ecological adaptation (2)
3 MIN READ
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Conserved biophotonic emissions
7 MIN READ
2
Antithetical conclusions (4)
3 MIN READ
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Anthetical conclusions (2)
5 MIN READ
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Non-random pheromone-controlled cell type differentiation
3 MIN READ
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RNAi: From magic bullet to billion dollar baby
4 MIN READ
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Energy-dependent natural fluorescence and bioluminescence
2 MIN READ
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GC-rich neo-Darwinian train wreck
5 MIN READ
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Biophotonics, glycobiology, quantized biodiversity
4 MIN READ
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The tipping point? 50,000 publications (5)
3 MIN READ
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Light ‘drives’ adaptation; nothing ‘drives’ evolution
6 MIN READ
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RNA methylation (revisited)
< 1 MIN READ
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Major transition ends use of silly theories
5 MIN READ
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Energy-dependent RNA methylation (8)
4 MIN READ
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Energy-dependent RNA methylation (3)
10 MIN READ
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Virus-driven energy theft: definition?
5 MIN READ
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Magic, Miracle, or Molecular Mechanism (3)
2 MIN READ
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Energy-dependent creation and entropy
4 MIN READ
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RNA-mediated physics, chemistry, and molecular epigenetics (3)
5 MIN READ
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MicroRNAs and/or QTLs: Who buried what?
2 MIN READ
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A bumper crop of virus-infected weeds and people
2 MIN READ
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Creating gravity, nucleic acids, receptors, and supercoiled DNA (2)
9 MIN READ
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Neuroscience Virtual Event vs AAAS Symposium
3 MIN READ
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The radical pair mechanism of ecological speciation
3 MIN READ
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Origin and evolution of the genetic code
2 MIN READ
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Teleophobes vs teleophiles: a recent history
2 MIN READ
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Ecological genomics: teleophobes respond (too late)
10 MIN READ
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Finding peace and π in the light of H bond energy (2)
8 MIN READ
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RNA methylation, RNA-directed DNA methylation, learning and memory
3 MIN READ
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Finding peace and π in the light of H bond energy
5 MIN READ
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Epigenetic (re)programming of behavior (3)
5 MIN READ
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RNA-mediated theory killers (6) (7) (8) (9) (10)
5 MIN READ
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Ecological adaptations you cannot live without
6 MIN READ
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RNA-mediated regulatory mechanisms link microbes to humans (3)
5 MIN READ
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Natural cooperation and Evolution 2.0
6 MIN READ
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Hydrogen-Atom Transfer in DNA Base Pairs
9 MIN READ
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Positive feedback loops and epigenetic traps
2 MIN READ
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Understanding cell type differentiation
3 MIN READ
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Biophysically constrained or unconstrained?
2 MIN READ
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Virucidal effects on ecological speciation
5 MIN READ
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Somatic hypermutation vs RNA-mediated events
2 MIN READ
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Decreased phenotypic variation: Faith in Facts
7 MIN READ
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Living the life that randomness created? (Sarcasm alert)
3 MIN READ
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Protein isoforms do not evolve
3 MIN READ
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Finding odor and taste receptors everywhere
6 MIN READ
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Nutrient-dependent RNA interference
4 MIN READ
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Silencing genes and serious scientists
3 MIN READ
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Deeply ingrained thoughts
< 1 MIN READ
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Viruses and ecologically adapted animals
2 MIN READ
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Correctly modeling life on this planet
3 MIN READ
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Correctly modeling ecological adaptation
4 MIN READ
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Behavior (4): All responses are RNA-mediated in birds
4 MIN READ
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Reverse phosphorylation
7 MIN READ
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Nutritional epigenetics, exercise, and immune system integrity
4 MIN READ
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RNA-protein interactions reveal biophysical to ecological landscapes
2 MIN READ
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ISHE's human ethology group
2 MIN READ
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Understanding cell type differentiation
3 MIN READ
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Thermodynamic constraints and ecological adaptations sans evolution
6 MIN READ
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RNA-mediated species specificity
2 MIN READ
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Intelligent viruses and cancers?
10 MIN READ
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ALPHA GENOMIX
7 MIN READ
2
RNA-mediated cell type differentiation and behavior
3 MIN READ
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Nutrition, pheromones and cancer (2)
2 MIN READ
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Darwinian theories vs Darwin's facts
2 MIN READ
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Pheromones and cancer
4 MIN READ
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A flawed model: no tripartate synapse in the adult brain
3 MIN READ
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[…] 8 hours from the time I posted Coherently organized healthy longevity (1) to my blog site at RNA-mediated.com, Quanta Magazine regurgitated this claim from […]