The Darwin Code: Resurrected after 20 years (2)

By: James V. Kohl | Published on: January 1, 2020

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Structural diversity of supercoiled DNA 10/12/15

Our cryo-ET, biochemical, and computational studies show the astounding versatility and dynamism of DNA depending on the degree of supercoiling. DNA simultaneously exists in a largely inactive B-form with bases tucked in and protected and an active, highly varied structure with exposed bases. Our data provide relative comparisons of supercoiling-dependent twisted, writhed, curved, and kinked conformations and associated base exposure. Each of these structural features may be differentially recognized by the proteins, nucleic acids, and small molecules that modulate DNA metabolic processes.

The light-activated energy-dependent creation of microRNAs is the link to the “small molecules that modulate DNA metabolic processes.”
See: “sickle cell” microRNA

Placenta Growth factor mediated gene regulation in Sickle cell disease 8/16/17

The identification of transcription factors which regulate the expression of host genes for miRNAs presents a novel therapeutic approach to modulate the expression of miRNA-target genes involved in disease pathophysiology.

See for comparison: Could gene therapy cure sickle cell anemia? 12/29/19
The obvious answer is no. They should admit that what they are calling gene therapy is energy-dependent microRNA-mediated biophysically constrained viral latency.
For comic relief from claims that gene editing may help cure defective signalling pathways in microRNA-mediated diseases such as sickle cell, see this from 12/10/14

See also: 3/30/16

Pseudoscientists have since linked the virus-driven degradation of mRNA to the evolution of the primate brain
See: How an Ancient Virus Spread the Ability to Remember (video with transcript) 12/13/19

1) …Shepherd discovered that, at a biological level, the process of memory storage strongly replicates that of viral transmission.

2) …ARC gene came from an ancient viral infection or retrotransposon insertion over 400 million years ago in an ancestor…

3) …and maybe this chance event led to the evolution of brains that allowed land animals to adapt to every niche on earth.

For comparison, see: MicroRNA-34a Acutely Regulates Synaptic Efficacy in the Adult Dentate Gyrus In Vivo 11/21/19

…findings are the first to demonstrate acute…regulation of synaptic efficacy in the adult brain by a miRNA.”

MicroRNA-mediated regulation of synaptic efficacy is energy-dependent. They linked the Creation of energy from energy-dependent changes in the assembly of the microRNA-RNA-peptide anocomplex to polycombic ecological adaptations. The adaptations prevent the hecatombic evolution of all diseases.
Compare claims about the virus-driven origin of the ARC gene to claims supported with citations from this Precision Medicine virtual conference.

Theorists are still making claims about the virus-driven creation of genes. Serious scientists start with the Creation of the sun’s anti-entropic virucidal energy; the Creation of water; and the oxygen-dependent ecological adaptations that link oxidative phosphorylation from the creation of ATP to the creation of RNA.
Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism and a type of “oxidative phosphorylation”

The synthesis of RNA in isolated thymus nuclei is ATP dependent.

See also: Olfaction Warps Visual Time Perception 3/17/17
See: Virus-mediated archaeal hecatomb in the deep seafloor 10/12/16
Who still believes that viruses create biophysically constrained genes? Why?
See: “We inadvertently missed citing two relevant papers in the Introduction and Results sections of our paper.” 3/22/18

They missed everything known to all serious scientists about how the energy-dependent assembly of the microRNA-RNA-peptide nanocomplex was linked to our visual perception of energy and mass in the context of the space-time continuum.

Cédric Feschotte is the co-author of the paper that linked his overwhelming ignorance from what they missed to the snake-centric theory of primate brain evolution via The Burmese python genome reveals the molecular basis for extreme adaptation in snakes and Did snakes help build the primate brain? 10/28/13

The big picture links all claims about the evolution of the human brain to pseudoscientific nonsense about the virus-driven evolution of genes. See for comparison Virus-mediated archaeal hecatomb in the deep seafloor 10/12/16

Again, I ask: Who still believes that viruses create the genes that biophysically constrain viral latency and healthy longevity? Why?