MicroRNA-mediated population control (6)

By: James V. Kohl | Published on: July 30, 2021

(click to enlarge)

7/29/21

I linked fixation of one amino acid substitution, EDAR V370A from the diet of human populations in East and central China to the New World during the past 5-10K years of ecological adaptations via https://nature.com/news/past-5-000-years-prolific-for-changes-to-human-genome-1.11912 WHO still hates me for doing that.

How?

“The findings confirm their earlier work suggesting that the majority of variants, including potentially harmful ones, were picked up during the past 5,000–10,000 years.”

Clearly, there has never been support for stupid theories about the emergence of energy from the cosmic void and the evolution of humans from pond scum during billions to millions of years of natural selection for beneficial mutations.
For contrast, more that 125,000 indexed published works that mention “microRNA” support claims that I have linked to microRNA-mediated population control across kingdoms via the physiology of reproduction, Biblical Genesis, and the fixation of amino acid substitutions, which protects all organized genomes from the virus-driven degradation of messenger RNA and all pathology.
For obfuscation of the facts, see: Amino acid metabolism and signalling pathways: potential targets in the control of infection and immunity 6/23/21

These processes include for a part a series of complex interactions between immune functions and metabolic pathways resulting from a convergent evolution of the two systems [1, 2].

In the context of convergent evolution of the overwhelmingly complex interactions linked to ecological adaptations across kingdoms, the author cites the Broad Institute‘s Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation. 5/25/12

Glycine metabolism may therefore represent a metabolic vulnerability in rapidly proliferating cancer cells that could in principle be targeted for therapeutic benefit.

God’s Creation of sunlight and humidity links the pH-dependent Creation of enzymes from His biophysically constrained placement of achiral glycine in position 6 of the gonadotropin releasing hormone (GnRH) decapeptide to the stability of organized genomes in all jawed vertebrates.
Some theorists claim that “evolution did it.” See: Evolution of Constrained Gonadotropin-releasing Hormone Ligand Conformation and Receptor Selectivity 11/18/05
Did evolution do this to all cell types in all tissues of all jawed vertebrates?
See: Figure 2 (Page 794) indicates that substitution of achiral glycine at position 6 stabilizes the folded conformation; increases binding affinity; and decreases metabolic clearance. “This feature is incorporated in all agonist and antagonist analogs.”
If evolution did not do this, Broad Institute researchers failed to link God’s Creation of anti-entropic virucidal light from plant growth to biophysically constrained viral latency across kingdoms via the physiology of reproduction and protonated RNA interference (RNAi).
Biden’s science advisor Eric Lander (president and founding director of the Broad Institute of MIT and Harvard) linked God’s Creation of anti-entropic virucidal light and humidity from color and fragrance of flowers to the patent for naturally occurring RNAi in 2012.

And then what? Eric Lander became a pro-jabber: a killer clown who promotes vaccinations, including those containing synthetic messenger RNA.
This tells all intelligent serious scientists, and most intelligent non-scientists that Lander and others like him (geneticists, molecular biologists, and mathematicians) cannot be trusted to tell the truth about how to prevent or effectively treat all virus-driven diseases via the patent for naturally occurring light-activated carbon fixation and RNA interference.
See for comparison the patent for the naturally occurring cure for all virus-driven pathology: RNA-Guided Human Genome Engineering

5. Repetitive elements or endogenous viral elements can be targeted with engineered Cas+gRNA systems in microbes, plants, animals, or human cells to reduce deleterious transposition…

Reduced deleterious transposition was linked to Analysis of 6,515 exomes reveals the recent origin of most human protein-coding variants via the claim:

“The findings confirm their earlier work suggesting that the majority of variants, including potentially harmful ones, were picked up during the past 5,000–10,000 years.”

To dispense with claims that this is merely RNA-mediated “circular logic” I add three examples of extant literature which were indexed on 7/30/21. Taken together they link epigenetic effects of virucidal light and humidity to biophysically constrained viral latency via chromosomal rearrangements that protect organized genomes across kingdoms via the physiology of reproduction and the patent for naturally occurring light-activated carbon fixation and protonated RNA interference held by George M. Church et al.

Transcriptomic analysis to reveal the differentially expressed miRNA targets and their miRNAs in response to Ralstonia solanacearum in ginger species 7/29/21

A total of 4736 and 4485 differential expressed miRTGs (DEmiRTGs) were identified in ginger and mango ginger, respectively, in response to R. solanacearum.

MicroRNAs 21 and 199a-3p regulate axon growth potential through modulation of Pten and mTor mRNAs 7/29/21

…the PTEN/mTOR pathway is regulated by micro-RNAs after neuronal injury and this modifies the capacity for translation of regeneration-associated genes in primary neurons.

The differential expression is caused by the virus-driven degradation of messenger RNA in R. solanacearum. Ecological adaptations across kingdoms are energy-dependent. The energy comes from sunlight.
Alterations of epigenetic landscape in Down syndrome carrying pregnancies: A systematic review of case-control studies 7/27/21

…dysregulation of epigenetic signatures including DNA methylation and microRNAs (miRNAs) crucially contribute to the pathomechanism of DS.