Funding the Human Genome Project-Write

By: James V. Kohl | Published on: July 21, 2016

The Genome Project-Write


…understanding of genetic blueprints could come from construction of large, gigabase (Gb)-sized animal and plant genomes, including the human genome, which would, in turn, drive development of tools and methods to facilitate large-scale synthesis and editing of genomes. To this end, we propose the Human Genome Project-Write (HGP-write), named to honor HGP-read but embracing synthesis of all large genomes.

My comment: Synthesis is nutrient energy-dependent and the synthesis of all large genomes links the innate immune system to the physiology of reproduction and supercoiled DNA, which protects all organized genomes from virus-driven entropy.
Synthesis of all genomes also is RNA-mediated, which explains why George Church and Luhan Yang are named in the patent application for RNA-guided human genome engineering.
Excerpt 2) 

The goal is to launch HGP-write in 2016 with $100 million in committed support, from public, private, philanthropic, industry, and academic sources from around the world. The costs of the project lie not only in obtaining de novo synthesized DNA but in the assembly, integration, and functional assays required to evaluate and understand the modified genomes. Total project costs are difficult to estimate but would likely be less than the $3 billion cost of HGP-read.

My comment: Funding the Human Genome Project-Write (HGP-write) will probably help George Church and others secure the patent and to deliver their “Billion Dollar Baby” ahead of schedule.  When others realize that the “Baby” exemplifies what is already known about RNA-mediated cell type differentiation in the context of the Precision Medicine Initiative and the National Microbiome Initiative,  all funding that has been wasted on projects that reinforce the views of pseudoscientists about mutations and evolution will be recognized as the biggest waste of money that any government has ever directly or indirectly sanctioned.
It is time to ask people like George Church to explain the difference between RNA-guided and RNA-mediated cell type differentiation or admit that they have known how it occurs in the context of biophysically constrained protein folding chemistry but are waiting to secure their patent(s) for maximum profit from the works of all others who know how to link angstroms to ecosystems in all living genera.

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