Energy-dependent RNA methylation (1)

By: James V. Kohl | Published on: June 5, 2016

“How often do we still hear that quantum effects can have little relevance in the study of biology, or even that we eat food in order to gain energy?” — Roger Penrose

“We know, for instance, when we eat food nucleic acids can get into our cells. Also, there is a theory that our cells in the body keep sending out nucleic acids and one theory has it that it seems to correct the mistakes that other cells have suffered from mutations. . . .” Mae-Wan Ho (2015)

See also: Study: Up to 90 percent of cancers not ‘bad luck,’ but due to lifestyle choices, environment

My comment: Anyone who claims the cause of morphological and/or behavioral diversity or the cause of cancer remains largely unknown is misrepresenting what is known to all serious scientists about biophysically constrained energy-dependent protein folding chemistry. All morphological and all behavioral diversity exemplifies how  energy-dependent RNA methylation must be linked from RNA-directed DNA methylation and fixation of RNA-mediated amino acid substitutions to all cell type differentiation in all individuals of all living genera. Fixation of the amino acid substitutions links metabolic networks from the innate immune system to genetic networks via the biophysically constrained physiology of energy-dependent reproduction.
If you continue to let theorists mislead you with their misrepresentations of biologically-based cause and effect, you may never link RNA methylation from metabolic networks to genetic networks. You will be of no use to those who are combating evolution to fight disease. Instead, you will be fighting against them on the side of ignorance and ridiculous theories.
Your army of ignorant theorists is being decimated by facts. I have nearly 10,000 citations in my bibliographic reference source to prove that. But everything I have detailed or could detail further is worthless if people do not look at the experimental evidence that already has been reported. Pseudoscientists must learn to incorporate facts into accurate representations of biologically-based cause and effect. That is the only way to compare facts to theories. If you are not willing to do that, do not expect someone else to keep doing it for you.
Instead, continue to revisit information that I have already detailed at or begin to make scientific progress towards your understanding of creation by examining what is already available for comparison and then begin to move on.
See for example: Epigenetic Control of Gene Expression failed to link energy-dependent changes from hydrogen-atom transfer in DNA base pairs in solution to biophysically constrained protein folding via detailed representations of how microRNAs and adhesion proteins link supercoiled DNA to the protection of all organized genomes from virus-driven energy theft and genomic entropy.
The university adds more injury to that insulting perspective on gene expression via this collaboration: The University of Melbourne is excited to announce a new partnership with Monash University to lift commercialisation and collaboration of research and innovation outcomes.
See the new course from the University of Copenhagen: Origins – Formation of the Universe, Solar System, Earth and Life


The story you are about to hear is mainly based on evidence from meteorites and we would therefore like to show you some particularly interesting examples.

My comment: You will be told a story that makes it appear as if theories about meteorites can be used by serious scientists to link top-down causation from energy-dependent changes in hydrogen-atom transfer in DNA base pairs in soluttion to what is known about metabolic networks and genetic networks in all living genera. What is known must link energy-dependent changes from angstroms to ecosystems and also link virus-driven energy theft to mutations and all pathology.

You will not be told anything about anti-entropic energy or virus-driven energy theft as you are taught to believe that their ridiculous theories are based on scientific evidence.


In the last set of lectures we will look the modern biodiversity, which is perhaps the most remarkable result of the evolution, which we have described throughout the course.There is an enormous difference between the biodiversity of different types of habitats on our planet – from the equator to the arctic, from deserts to rainforests, and from isolated islands like the Galapagos to large continents.

My comment: What will they teach about genetic entropy?

I’ve spent more time than I could have imagined during the past few weeks attempting to discuss experimental evidence of biologically-based cause and effect with biologically uninformed participants in FB groups. Antagonists refused to discuss the experimental evidence. Instead, secular humanists tried to try to get a consensus of opinions about how to define a creationist. Then someone mentioned they would need prevent anyone from defining evolutionists.

Once evolutionists and creationists were “defined,” it would be clear that secular humanists have nothing on which to base their beliefs. They just believe others have no scientific basis for their beliefs. Creationists do not seem to be much better off, and they are clearly as antagonistic. See, for example:

Well, James Kohl has been an embarrassment for this group, attacking other members calling them ignorant and also trolling other groups, this is not what a Christian is supposed to behave.

I do not attack. I inform. If the people I inform chose to not learn anything about the difference between theories and experimental evidence that establishes fact about biologically-based cause and effect, I typically complain that they are biologically uninformed and can be provoked into referring to them as biologically uninformed science idiots. It doesn’t take much to provoke me. If I ask some one to search PubMed for information to be used in the context of discussion, I usually supply a link from my search strategy.

See for example: m6A and microRNA and m6A microRNA mrna
By adding “mRNA” to the search strategy, this citation is lost:

Novel RNA regulatory mechanisms revealed in the epitranscriptome

Others might never learn that the novel RNA regulatory mechanisms were first mentioned in 2013, and they would probably miss this:



The virulent bacteriophage-host cell system is an example of a phenomenon involving recognition by the host of a foreign nucleic acid; in some instances, phage DNA is rapidly synthesized while the host DNA is rapidly degraded. If methylated bases are involved in controlling such a recognition mechanism, then a study of the methylated base content of 7′ DNA’s of various bacteriophages grown in different hosts might provide a clue as to the biological function of the methylating enzymes.

My comment: Until you learn about virus-driven energy theft, this authors’ comment from 2013 would  be meaningless.

The major antigenic changes of the influenza virus are primarily caused by a single amino acid near the receptor binding site.

One of the secular humanists I encountered took that claim and every aspect of RNA-mediated cell type differentiation that I have detailed during the past 20 years, and represented it here:

See: Virus Driven Energy Theft


If you are a creation scientist, you can take comfort in the fact that as you get older, the control of these viral fragments is considerably weakened, and eventually one or more of these jumping genes will be let loose in your body to wreak havoc on your DNA. When that happens, you can thank God, because they will have brought you closer to him.

My comment: It is difficult for me to imagine how anyone could remain so horribly uninformed or how anyone could become such a hate-monger. For example, virus-driven energy theft is linked to pathology throughout life, not just in old age.

See for example: Maternal Inflammation Disrupts Fetal Neurodevelopment via Increased Placental Output of Serotonin to the Fetal Brain


SIGNIFICANCE STATEMENT The mechanisms linking maternal inflammation during pregnancy with increased risk of neurodevelopmental disorders in the offspring are poorly understood.

My comment: In the introductory statement of this blog post, I wrote: “Anyone who claims the cause of morphological and/or behavioral diversity or the cause of cancer remains largely unknown is misrepresenting what is known to all serious scientists about biophysically constrained energy-dependent protein folding chemistry.” The significance statement was published with the article in the Journal of Neuroscience and reported as: Flu-like symptoms in pregnant woman could affect baby

Levels of tryptophan, an amino acid that activates the immune system, increased, causing the placenta to produce more serotonin, which led to higher concentrations of serotonin in the fetal brain.

Excerpt (with my emphasis): “The study provides a new molecular pathway to understanding how prenatal insults could program a baby to eventually develop mental diseases. Even mild viral attacks such as the flu or Zika virus, which generally does not require a mother to visit to the doctor’s office, might affect the development of a baby’s central nervous system…”
My comment: The article published in the Journal of Neuroscience did not mention the link between the nutrient energy-dependent amino acid and activation of the immune system. If they had it would suggest that no new molecular pathway has been discovered. Virus-driven energy theft has always been linked via a single amino acid substitution in the virus to all pathology in all living genera.
Getting researchers to report that fact in the context of their findings has been a challenge. Until someone establishes a clear link from energy-dependent RNA methylation to behavior and publishes in a journal such as the Journal of Neuroscience, others may not examine other experimental evidence that clearly links viruses like the Zika virus to changes in morphological phenotypes and behavioral phenotypes via differences in energy-dependent brain development.

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