WHO broke the breakthough (9)

By: James V. Kohl | Published on: April 29, 2023

Optimal Nutritional Status for a Well-Functioning Immune System Is an Important Factor to Protect against Viral Infections (4/23/20) Facts about RNA-peptide interactions at the origin of life and the origin of consciousness were linked to moronic theories in the current issue of Science Magazine.

See: Zoonomia 4/27/23

Search for the articles included: zoonomia consortium to read how much pseudoscientific nonsense is linked to the energy-dependent biophysically constrained Creation of new species.

See:

Relating enhancer genetic variation across mammals to complex phenotypes using machine learning

“Protein-coding differences between species often fail to explain phenotypic diversity…”

Protein folding chemistry is epigenetically effected and biophysically constrained by the physiology of reproduction across kingdoms.

Leveraging base-pair mammalian constraint to understand genetic variation and human disease

“…the regulatory landscape of the human genome still needs to be further explored and linked to disease.”

The virus-driven degradation of messenger RNA (mRNA) has been linked to all diseases since the origin of life and origin of consciousness.

Three-dimensional genome rewiring in loci with human accelerated regions

“…comparative genomics together with models of 3D genome folding revealed enhancer hijacking as an explanation for the rapid evolution of HARs.”

Light activated carbon fixation in cyanobacteria biophysically constrains pH-dependent miRNA-mediated reproduction. Use of the term “enhancer hijacking” obfuscates every aspect of top-down quantum causation, physics, chemistry, and molecular epigenetics.

Integrating gene annotation with orthology inference at scale

‘TOGA implements a different paradigm to infer orthologous loci, improves ortholog detection and annotation of conserved genes compared with state-of-the-art methods, and handles even highly fragmented assemblies.”

Inferences were eliminated by facts that link natural selection for energy-dependent codon optimality to Darwin’s “conditions of life” via the physiology of reproduction.

Evolutionary constraint and innovation across hundreds of placental mammals

Of 101 million significantly constrained single bases, 80% are outside protein-coding exons and half have no functional annotations in the Encyclopedia of DNA Elements (ENCODE) resource.

The energy-dependent changes in genes and regulatory elements link fixation of amino acid substitutions to exceptional mammalian traits via the physiology of reproduction in bacteria, which links mutations to imperiled biodiversity in the context of 6515 genetic variants that have been linked to the origin of life ~6000 years ago via analysis of 6,515 exomes, genome function and organismal phenotypes.

The functional and evolutionary impacts of human-specific deletions in conserved elements

“We identified and characterized 10,032 human-specific conserved deletions (hCONDELs). These short (average 2.56 base pairs) deletions are enriched for human brain functions across genetic, epigenomic, and transcriptomic datasets.’

Their data provide no facts that might otherwise be linked to the evolutionary mechanisms that they claim drive new traits in humans and other species.

​Comparative genomics of Balto, a famous historic dog, captures lost diversity of 1920s sled dogs

“We propose that Balto’s population of origin, which was less inbred and genetically healthier than that of modern breeds, was adapted to the extreme environment of 1920s Alaska.”

If the population of origin fails to adapt, the species becomes extinct.

A genomic timescale for placental mammal evolution

“We compared neutral genome-wide phylogenomic signals using concatenation and coalescent-based approaches, interrogated phylogenetic variation across chromosomes, and analyzed extensive catalogs of structural variants.”

Food energy-dependent pheromone-controlled chromosomal rearrangement in species from flies to humans link ecological adaptation to all biodiversity.

Mammalian evolution of human cis-regulatory elements and transcription factor binding sites

“Genes near constrained elements perform fundamental cellular processes, whereas genes near primate-specific elements are involved in environmental interaction, including odor perception and immune response.”

Odor perception and the immune response link food odors and pheromones to biophysically constrained viral latency via RNA interference (RNAi) across kingdoms.

The contribution of historical processes to contemporary extinction risk in placental mammals

“Models that included genomic data were predictive of species’ conservation status, suggesting that, in the absence of adequate census or ecological data, genomic information may provide an initial risk assessment.”

Models that fail to link ecological data to species’ conservation status cannot be validated. They are missing key elements of the links from top-down quantum causation to coherently organized biology via the Creation of miRNAs in exosomes.

Insights into mammalian TE diversity through the curation of 248 genome assemblies

“Mammals tend to accumulate only a few types of TEs at any given time, with one TE type dominating. We also found association between dietary habit and the presence of DNA transposon invasions.”

Pardis Sabeti’s group linked a single base pair change, from EDAR V370A polymorphisms to differences in morphological and behavioral phenotypes across human populations in 2013.


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