Enzyme-constrained interethnic biodiversity (5)

By: James V. Kohl | Published on: January 10, 2018

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Conclusion: The problem with -omics is that biologically uninformed researchers keep throwing more bricks into the brickyard but they fail to use any of the bricks to build a model of anything akin to how the energy-dependent functional structure of supercoiled DNA or its diversity is created.
The biologically uninformed pseudoscientists end up creating only a brick yard or building a partially constructed wall that prevents serious scientists from getting to the facts about supercoiled DNA
The Structural diversity of supercoiled DNA is literally and figuratively “All about that base” That fact was also accurately represented in the context of the academic swamp in the song by Pink Floyd: “Another Brick in The Wall.”
The virus-driven theft of quantized energy alters base pairs, which causes the degradation of messenger RNA to spread from cell to cell and from undifferentiated cell types to differentiated cell types that become undifferentiated.
See also: Alzheimer’s protein may spread like an infection, human brain scans suggest

…the finding may illuminate how neurodegeneration occurs in the devastating illness, and it could provide new ideas for stemming the brain damage that robs so many of memory and cognition.

Viruses cause the neurodegeneration. That fact has repeatedly been illuminated in the context of UV light induced RNA-mediated DNA repair.
See: UV-Induced Charge Transfer States in DNA Promote Sequence Selective Self-Repair

The involvement of two bases for the repair points to a long-living charge transfer state between G and A to be responsible for the repair. The negatively charged A radical anion donates an electron to the CPD, inducing ring splitting and repair. In contrast, a TA sequence, having an inverted charge distribution (T radical anion, A radical cation), is not able to repair the CPD lesion. The investigations show that the presence of an adjacent radical ion is not sufficient for repair. More likely it is the driving power represented by the oxidation potential of the radical ion, which controls the repair. Thus, repair capacities are strongly sequence-dependent, creating DNA regions with different tendencies of self-repair. This self-healing activity represents the simplest sequence-dependent DNA repair system.

I reiterate: RNA-mediated DNA repair is energy-dependent.
See: Stem Cell Therapeutics Corp.

Stem Cell Therapeutics Corp. is a public biotechnology company (TSX VENTURE:SSS) focused on the development and commercialization of drug-based therapies to treat central nervous system diseases. SCT is a leader in the development of therapies that utilize drugs to stimulate a patient’s own resident stem cells. The Company’s programs aim to repair brain and nerve function lost due to disease or injury. The Company’s extensive patent portfolio of owned and licensed intellectual property supports the potential expansion into future clinical programs in numerous neurological diseases such as traumatic brain injury, multiple sclerosis, Huntington’s disease, Alzheimer’s disease, and ALS.

See also: In addition to effectively stimulate the cells of specific organ systems, these new and energetic stem cells act quickly to revitalize the body immune system & defense mechanisms.
Energetic stem cells…. Get it?
See also: Pheromones and the luteinizing hormone for inducing proliferation of neural stem cells and neurogenesis
All serious scientists know that they pheromone-controlled physiology of reproduction biophysically constrains viral latency. That fact led some serious scientists to study human pheromones as the most likely form of species-specific treatment for neurodegenerative diseases and for other diseases.
All forms of pathology have since been addressed in the context of how changes in SNPs link energy-dependent changes in base pairs to the fixation of RNA-mediated amino acid substitutions that differentiate all cell types in all living genera. SNP genotyping links energy-dependent changes in electrons to beneficial changes in ecosystems.
See: Ramping up PCR for SNP genotyping December 21, 2017

…in rhPCR, a mismatch at or near the RNA base inhibits the ability of RNase H2 to unblock an rhPCR primer. This unique property can be used as a basis for accurate SNP identification—the additional specificity requirements ensure only correct allelic matches are amplified to produce signal. Such assays have been developed by scientists and yield excellent results.

See also: SNP genotyping
For example: The rs1127354 Polymorphism in ITPA Is Associated with Susceptibility to Infertility.
The ability of energy-dependent endogenous substrates and enzymes to donate or receive an H is affected by the potential of hydrogen (pH.) The optimal pH links hydrogen-atoms in DNA base pairs in solution to the de novo creation of different enzymes. In that context, the enzymes link metabolism of food to the pheromones that biophysically constrain viral latency. Constraint-breaking mutations are linked to infertility by the failure of energy-dependent error-free DNA repair.
Obviously, as indicated above, serious scientists have linked food energy-dependent changes in electrons from hydrogen-atom transfer in DNA base pairs in solution via SNPs and the energy-dependent fixation of amino acid substitutions. Simply put: Feedback loops link odor and pheromone signaling with reproduction. But also see: Hypothalamic microRNAs flip the switch for fertility and From Fertilization to Adult Sexual Behavior.
Unfortunately, biologically uninformed pseudoscientists and other theorists are only now beginning to attest to the fact that autophagy is the link from hydrogen-atom transfer in DNA base pairs in solution to cellular senescence and to cellular reprogramming via changes in pH.
The Link Between Cellular Senescence and Cellular Reprogramming January 5, 2018

Today, we have a new paper that discusses how induced pluripotency and cellular senescence, two of several possible cellular states, share similarities[2]. It is likely no surprise that the two states are closely related and that some of the mechanisms for one process are shared by the other. It appears that certain key signaling molecules are important in determining both cell fate and senescence.

The creation of signalling molecules is pH-dependent. No signalling occurs outside the context of the constrained or unconstrained energy in a hydrogen atom.

The key signalling molecules biophysically constrain viral latency. A cartoon representation of Long-range coherence and energy storage in biological systems (1968) might help others establish facts about how the construction of the cell membrane protects against virus-driven genomic entropy.

See for example: A comic about the problems with the -omics, illustrated by Matteo Farinella
The problem with -omics is that biologically uninformed researchers keep throwing more bricks into the brickyard but they fail to use any of the bricks to build a model of anything akin to how the energy-dependent functional structure of supercoiled DNA or its diversity is created.
The biologically uninformed pseudoscientists end up creating only a brick yard or building a partially constructed wall that prevents serious scientists from getting to the facts about supercoiled DNA
From the January 8, 2018 close of trading.