alternative splicings

Virus-perturbed alternative splicings

Computing in mammalian cells with nucleic acid strand exchange Abstract excerpt: …we established that functional siRNA could be activated through strand exchange, and used native mRNA as programmable scaffolds for co-localizing gates and visualizing their operation with subcellular resolution. Reported as: Scientists Demonstrate Basics of Nucleic Acid Computing Inside Cells Excerpt: Cells, of course, already know how to sense toxic molecules and the development malignant tendencies, and to then take action. But those safeguards can be turned off by viruses…

Read More

RNA methylation, RNA-directed DNA methylation, learning and memory

sink testing Lab medicine The illegal practice of providing false test results on clinical specimens–eg, vials of blood, urine specimens, that were deliberately discarded–ie, down the sink, without actually testing them Pylori Story #1: Acid Attack Pylori Story #2: Journey to the Center of the Stomach The “Modern Synthesis” is analogous to sink testing in the medical laboratory. See for example: Replace the Modern Synthesis (Neo-Darwinism): An Interview With Denis Noble Excerpt: [W]hat Haldane, Fisher, Sewell Wright, Hardy, Weinberg et…

Read More

Perry Marshall: too much information for atheist PZ Myers

Atheist PZ Myers Debates Perry Marshall Darwinism vs. Evolution 2.0 on “Unbelievable?” Excerpt: Contrary to what PZ said, McClintock’s work is explicitly about cells engineering solutions! That is her point. My comment: Perry Marshall shows how difficult it is to discuss biological facts with those who are biologically uninformed. PZ Myers ignores everything known about how the innate immune system is designed to ensure cell type stability and the nutrient-dependent stability of organized genomes. That nutrient-dependent stability is maintained across…

Read More

The stability of organized genomes (4)

Note: Replication stress can be linked from nutrient stress or from social stress to thermodynamic cycles of protein biosynthesis and degradation. Stress induced pathologies arise in the context of virus perturbed protein folding, Healthy longevity arises in the context of nutrient-dependent RNA-mediated gene duplication and fixation of RNA-mediated amino acid substitutions in organized genomes via the physiology of reproduction. Others have now linked stress to cancer but they have not linked RNA-mediated amino acids substitutions and ecological adaptations to healthy…

Read More

Nutritional epigenetics, exercise, and immune system integrity

Anti-inflammatory mechanism of dieting and fasting revealed Summary: Researchers have found that a compound produced by the body when dieting or fasting can block a part of the immune system involved in several inflammatory disorders such as type 2 diabetes, atherosclerosis, and Alzheimer’s disease. My comment: For the obvious link from nutrition and exercise to reproduction and RNA-mediated transgenerational epigenetic effects on the morphological and behavioral phenotypes of all species that must “move” to find food or to find mates…

Read More

Intelligent viruses and cancers?

The Very Intelligent Ebola Virus Takes Front and Center Excerpt 1) “Ebola doesn’t enter the nucleus. It uses the cell’s machinery of ribosomes and transfer RNA to make proteins from the viral messengerRNA.” Excerpt 2) “Normally, mechanisms inside the nucleus have complex relations with messenger RNA and the alternative RNA editing process (see RNA alternative editing post). Specific protein complexes help splice the messengerRNA before it is sent from the nucleus to the ribosomes in the cytoplasm to make proteins.”…

Read More

Genomic surveillance ends our world of RNA-mediated ecological adaptations

Why is this woman smiling? 1) Identifying Recent Adaptations in Large-Scale Genomic Data Senior author: Sabeti with co-author Rinn Excerpt: “As natural selection can only act on mutations that drive phenotypic variation…”. 2) Genomic surveillance elucidates Ebola virus origin and transmission during the 2014 outbreak  Senior author: Sabeti. Excerpt: “Because many of the mutations alter protein sequences and other biologically meaningful targets, they should be monitored for impact on diagnostics, vaccines, and therapies critical to outbreak response.” 3) RNA and…

Read More

Genotype, observed phenotype, and distinctly disordered behaviors

Schizophrenia not a single disease but multiple genetically distinct disorders September 15, 2014 By Jim Dryden News article excerpt: “Genes don’t operate by themselves,” said C. Robert Cloninger, MD, PhD, one of the study’s senior investigators. “They function in concert much like an orchestra, and to understand how they’re working, you have to know not just who the members of the orchestra are but how they interact.” My comment: Robert Cloninger and Jay R. Feierman were psychiatry post-doc residents at…

Read More

RNA-mediated ecological adaptation is not evolution

Prehistoric Critters Change View of Mammal Evolution Three extinct squirrel-like species were identified from Jurassic-era fossils in China. By Molly Sharlach | September 12, 2014 Excerpt 1): “The fossils suggest that the slender animals spent time in trees, and had hands and feet adapted for grabbing branches. Their resemblance to present-day squirrels is a result of convergent evolution, as they belong to a lineage that diverged from that of modern mammals long ago.” My comment: Resemblance in the fossil record…

Read More

Exploding genomes and chromosomal rearrangements via RNA-mediated events

Gibbon genome and the fast karyotype evolution of small apes This is an open access article reported as: Gibbon genome sequence deepens understanding of primates rapid chromosomal rearrangements Excerpt: The number of chromosomal rearrangements in the gibbons is remarkable, Rogers said. “It is like the genome just exploded and then was put back together,” he said. “Up until recently, it has been impossible to determine how one human chromosome could be aligned to any gibbon chromosome because there are so…

Read More