alternative splicings

Energy-dependent purifying selection / autophagy (4)

Energy-dependent purifying selection / autophagy (3) My question: What is an abiotic environment? See: “abiotic factors found in aquatic systems may be things like water depth, pH, sunlight, turbidity (amount of water cloudiness), salinity (salt concentration), available nutrients (nitrogen, phosphorous, etc.), and dissolved oxygen (amount of oxygen dissolved in the water). Abiotic variables found in Energy-dependent purifying selection / autophagy (4)

Coulombic interactions facilitate polycombic adaptation

RNA Structural Modules Control the Rate and Pathway of RNA Folding and Assembly Summary: Everything known to serious scientists about energy-dependent biophysically constrained RNA-mediated protein folding chemistry is attributed to “Nature” and evolution with no consideration for where the energy came from or where it goes when viruses use it for their replication. See also: Coulombic interactions facilitate polycombic adaptation

80 years of causal analysis (1936 – 2016)

Roles of Mutation and Selection in Speciation: From Hugo de Vries [1902 definition of mutation] to the Modern Genomic Era Excerpt: …mutation is crucial in speciation because reproductive barriers cannot be generated without mutations. My comment: Chromosomal rearrangements link autophagy from energy-dependent changes in RNA-mediated amino acid substitutions and supercoiled DNA to all biodiversity via 80 years of causal analysis (1936 – 2016)

Light energy-dependent active motifs

Active Motif claims that Active Motif is the industry leader in developing and delivering innovative tools to enable epigenetics and gene regulation research. See how the role of light is portrayed in LightSwitch™ Luciferase Assay System (with my emphasis) Excerpt 1) Combined with our large collection of miRNA Mimics and Inhibitors, you have everything needed Light energy-dependent active motifs

Anthetical conclusions (2)

From Fertilization to Adult Sexual Behavior (1996) …ribosomal proteins S4X and S4Y (rpS4X, rpS4Y) are produced by sexually dimorphic genes whose protein products are sexually dimorphic. This suggests the possibility of subtle nuances in the ribosomal translation of at least some mRNA, in certain cell types (Fisher et al.,1990; Zinn et al., 1994). Small intranuclear Anthetical conclusions (2)

GC-rich neo-Darwinian train wreck

Targeted Epigenetic Remodeling of Endogenous Loci by CRISPR/Cas9-Based Transcriptional Activators Directly Converts Fibroblasts to Neuronal Cells Excerpt: In this study, we demonstrate direct cellular reprogramming to induced neuronal cells through targeted activation of endogenous genes. Excerpt: Moreover, a recent study demonstrated that reprogramming efficiency can be limited by divergence to a competing cell identity (Treutlein GC-rich neo-Darwinian train wreck

Effects on invertebrate GnRH and affects on primate behavior

Introduction: Energy-dependent changes in hydrogen-atom transfer in DNA base pairs in solution have again been linked to hormone-organized and hormone-activated behaviors by the conserved molecular mechanisms we detailed in the molecular epigenetics section of our 1996 Hormones and Behavior review. The practical application of those details has been reported in the context of this article, Effects on invertebrate GnRH and affects on primate behavior

Virus-perturbed alternative splicings

Computing in mammalian cells with nucleic acid strand exchange Abstract excerpt: …we established that functional siRNA could be activated through strand exchange, and used native mRNA as programmable scaffolds for co-localizing gates and visualizing their operation with subcellular resolution. Reported as: Scientists Demonstrate Basics of Nucleic Acid Computing Inside Cells Excerpt: Cells, of course, already Virus-perturbed alternative splicings

RNA methylation, RNA-directed DNA methylation, learning and memory

sink testing Lab medicine The illegal practice of providing false test results on clinical specimens–eg, vials of blood, urine specimens, that were deliberately discarded–ie, down the sink, without actually testing them Pylori Story #1: Acid Attack Pylori Story #2: Journey to the Center of the Stomach The “Modern Synthesis” is analogous to sink testing in RNA methylation, RNA-directed DNA methylation, learning and memory