base editing

MicroRNA-mediated healthy longevity (3)

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Unraveling the Molecular Signature of Extracellular Vesicles From Endometrial-Derived Mesenchymal Stem Cells: Potential Modulatory Effects and Therapeutic Applications 12/20/19 Photosynthesis has been linked to: The biological mechanisms underlying endMSCs function have been associated to their immunomodulatory capacity (Nikoo et al., 2012), which is mediated—at least in part—by indoleamine 2,3-dioxygenase-1, cyclooxygenase-2, IL-10, and IL-27 (Peron et … MicroRNA-mediated healthy longevity (3)

Bruce McEwen’s retrovirus legacy (2)

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From CRISPR Multiplexing to Pleistocene Park 1/3/20 Genome science pioneer George Church envisions technologies of unprecedented power—and applications of breathtaking scope The discussion questions were tailored to avoid representations of facts that others have linked to patented cures for all pathology. For instance, George M. Church has linked God’s Creation of sunlight and water to … Bruce McEwen’s retrovirus legacy (2)

Bruce McEwen’s legacy: sympatric speciation (3)

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Recent additions to the available information on energy-dependent microRNA-mediated cause and effect can be found in:  Bruce S. McEwen’s legacy: sympatric speciation (2) Moving forward: On the day after Bruce S. McEwen died, the preprint for Integrated analysis of directly captured microRNA targets reveals the impact of microRNAs on mammalian transcriptome 6/15/19 was published in … Bruce McEwen’s legacy: sympatric speciation (3)

Bruce S. McEwen’s legacy: sympatric speciation (2)

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The ever increasing number of publications that link microRNA-mediated top down causation to prevention of virus-driven pathology attests to the facts from Biology could be so much more 11/22/19 …all that hard-earned expertise can get in the way. After all, nature isn’t neatly divided along disciplinary lines, so understanding it requires an integrated way of … Bruce S. McEwen’s legacy: sympatric speciation (2)

Bruce S. McEwen’s legacy: sympatric speciation (1)

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Neuroscientist Bruce McEwen, who studied the impact of stress on the brain, has died 1/3/20 McEwen’s work has profound implications for public health, impacting conditions from normal aging to neurodegenerative disease, depression, and PTSD. Historical perspective on his life’s works: 1/1/20 Happy New Year! Unless you are a biologically uninformed theorist. See:Human sperm displays rapid … Bruce S. McEwen’s legacy: sympatric speciation (1)

Virus-driven sympatric speciation (2)

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See first: Virus-driven sympatric speciation (1) See also: Profiling microRNAs through development of the parasitic nematode Haemonchus identifies nematode-specific miRNAs that suppress larval development 11/26/19 …these miRNAs suppress metabolic and transcription factor activity required for development. Those miRNAs link the diet-driven pheromone-controlled changes to sympatric speciation from C. elegans to the predator, P. pacificus and … Virus-driven sympatric speciation (2)

The tipping point (revisited): 96K (6)

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If you have not yet linked light-activated energy-dependent pheromone-controlled feedback loops to biophysically constrained viral latency and healthy longevity via the physiology of reproduction in species from microbes to mammals, you are biologically uninformed and you may be a pseudoscientist. Intelligent serious scientists will continue to follow the extant literature and eliminate all the pseudoscientific … The tipping point (revisited): 96K (6)

The tipping point (revisited): 96K (5)

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Helicobacter pylori Eradication Can Reverse the Methylation-Associated Regulation of miR-200a/b in Gastric Carcinogenesis. 1/3/10 [Korea] [The food energy-dependent pheromone-controlled biophysically constrained viral latency in gut bacteria and] Epigenetic alterations of miR-200a/b may be implicated in H. pylori-induced gastric carcinogenesis. This field defect for cancerization is suggested to be improved by H. pylori eradication. The light-activated … The tipping point (revisited): 96K (5)