RNA Directed

RNA-guided gene editing

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From June 14, 2015 Light induced RNA-mediated gene activation Eye-independent, light-activated chromatophore expansion (LACE) and expression of phototransduction genes in the skin of Octopus bimaculoides Energy-dependent RNA-mediated prevention of heart failure Small-molecule activation of SERCA2a SUMOylation for the treatment of heart failure Theoretical pseudoscientific nonsense Ancient DNA reveals how Europeans developed light skin and lactose … RNA-guided gene editing

Model vs theory: Progress report!

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On June 14, 2013, 1) Nutrient-dependent/pheromone-controlled adaptive evolution: a model and 2) Mutation-Driven Evolution were published with divergent/opposite conclusions. 1) …the largest contributor to the development of our personal preferences may be the unconscious epigenetic effects of food odors and pheromones on hormones that organize and activate behavior. If so, the model represented here is … Model vs theory: Progress report!

Masters of deception about nature (2)

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See my other blog posts on RNA methylation Thanks for your review of How Can Physics Underlie the Mind?: Top-Down Causation in the Human Context (The Frontiers Collection) Others linked the sun’s anti-entropic virucidal energy from energy-dependent changes in hydrogen-atom transfer in DNA base pairs in solution to supercoiled DNA, which protects all organized genomes … Masters of deception about nature (2)

Masters of deception about nature

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Masters of Physics in Nature Excerpt: This interaction raises the possibility that particle velocity information and electrical information, and interactions between them, can be encoded by a single hair.” It also raises the possibility that “electroreception is widespread in arthropods, fulfilling functions beyond the detection of floral electric fields. My comment: Energy-dependent microRNA flanking sequences … Masters of deception about nature

The Mind’s Eyes (revisited)

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Author’s copy: The Mind’s Eyes: Human pheromones, neuroscience, and male sexual preferences (2007) Abstract: The across-species genetic conservation of intercellular and extracellular chemical communication enables unicellular and multicellular organisms to functionally distinguish between self and non-self.  Non-self olfactory/pheromonal input from the social environment elicits a vertebrate neuroendocrine response.  The organization and activation of this neuroendocrine … The Mind’s Eyes (revisited)

RNA methylation, behavior, and disease

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Epigenetics and Genetics of Viral Latency by Paul M. Lieberman (May 11, 2016)   My comment: Lieberman succinctly confirmed the fact that …viral latency is responsible for life-long pathogenesis and mortality risk… His simplistic conclusion also attests to the fact that there is no defined boundary between epigenetics and genetics. Epigenetic effects on metabolic networks must … RNA methylation, behavior, and disease

Modelling life scientifically: RNA-mediated events

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Experiment: “An attempt to arrive at an accurate result.” — James V. Kohl (3/27/16) EFBC fellowship class response to Dr. Tom Jordan who asked me to define “experiment” For comparison, see: Experiment: An experiment is a procedure carried out to verify, refute, or validate a hypothesis. Experiments provide insight into cause-and-effect by demonstrating what outcome … Modelling life scientifically: RNA-mediated events

Energy-dependent RNA methylation (10)

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Plexciton Dirac points and topological modes Reported as: Scientists design energy-carrying particles called ‘topological plexcitons’ Excerpt: This should eventually enable engineers to create plexcitonic switches to distribute energy selectively across different components of a new kind of solar cell or light-harvesting device. My comment: “Single-residue insertion switches the quaternary structure and exciton states of cryptophyte … Energy-dependent RNA methylation (10)

Energy-dependent RNA methylation (8)

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Multiplexing Genetic and Nucleosome Positioning Codes: A Computational Approach Mutation Monte Carlo method (MMC): Excerpt: The mutation moves change the bp sequence but keep the DNA configuration fixed. Both moves change the energy, Eq (1), of the two bp steps involved. My comment: Moves that change energy cost energy. Attributing energy-dependent changes in base pairs … Energy-dependent RNA methylation (8)