Update: 2/28/22 Peptide synthesis at the origin of life 11/13/20 was linked to the origin of information via Footprints of a Singular 22-Nucleotide RNA Ring at the Origin of Life 4/25/20 two days after former President Trump linked God’s Creation of sunlight and humidity to weakened coronavirus pathology. Labroots Neuroscience virtual event: YouTube video < … The Origin of Information (1)
For review see my blog posts “The tipping point? 50,000 publications” with follow-ups: (2) (3) & (4). There are now more than 52,000 published works that link microRNAs to cell type differentiation in the context of healthy longevity or virus-driven energy theft, which has been linked from viral latency to all pathology. At the rate … The tipping point? 50,000 publications (5)
Codon identity regulates mRNA stability and translation efficiency during the maternal‐to‐zygotic transition Abstract: Cellular transitions require dramatic changes in gene expression that are supported by regulated mRNA decay and new transcription. The maternal-to-zygotic transition is a conserved developmental progression during which thousands of maternal mRNAs are cleared by post-transcriptional mechanisms. Although some maternal mRNAs are … Light ‘drives’ adaptation; nothing ‘drives’ evolution
So Many Research Scientists, So Few Openings as Professors Excerpt: Even someone as brilliant as Emmanuelle Charpentier, who in 2015 became head of the Max Planck Institute for Infection Biology after a momentous discovery in gene editing, spent the previous 25 years moving through nine institutions in five countries. My comment: Why did she move … Did “Nature” kill Steve Jobs? (3)
The Genome Project-Write Excerpt: …understanding of genetic blueprints could come from construction of large, gigabase (Gb)-sized animal and plant genomes, including the human genome, which would, in turn, drive development of tools and methods to facilitate large-scale synthesis and editing of genomes. To this end, we propose the Human Genome Project-Write (HGP-write), named to honor … Funding the Human Genome Project-Write
Engineers program E. coli to destroy tumor cells Excerpt: Certain strains of bacteria thrive in low-oxygen environments such as tumors, and suppression of the host’s immune system also creates favorable conditions for bacteria to flourish. My comment: The differences in the strains are nutrient-dependent and pheromone-controlled, which links them from RNA-mediated amino acid substitutions to … RNA-mediated programming of E.coli
See also: Did “Nature” kill Steve Jobs? In my model of biophysically constrained energy-dependent protein folding chemistry and RNA-mediated cell type differentiation, the nutrient-dependent pheromone-controlled physiology of reproduction links the innate immune system to supercoiled DNA, which protects all organized genomes from virus-driven entropy. For comparison to my model, see: Evolution 2016 Videos (Indexed) Youtube … Did “Nature” kill Steve Jobs? (2)
Interview with Greg Bear Excerpt: In Blood Music (1985) you explore nanotechnology with nanobots gone horribly wrong and when reading Silicon Times e-Book Review I couldn’t help drawing parallels…. Do you sometime get deja-vu moments when something you’ve written about suddenly almost is a reality? Bear’s accurate representations of virus-driven biologically-based cause and effect predicted … Nanotechnology and nanobots gone horribly wrong
The effects of virus-driven energy theft on brain development in mammals typically occur more rapidly during gestation and early prenatal development. That’s why the connection from biophysically constrained RNA-mediated amino acid substitutions and protein folding chemistry during life history transitions has been largely ignored. Persistent Structural Plasticity Optimizes Sensory Information Processing in the Olfactory Bulb … Virus-driven downsizing of the human brain (2)
N 6-Methyladenosine (m6A) Methylation in mRNA with A Dynamic and Reversible Epigenetic Modification Excerpt: …the reversible and dynamic m6A RNA methylation, the most prevalent internal modification in mRNA, plays broad and key roles in diverse biological processes. Through the functional interactions with m6A methyltransferases, demethylases, and m6A-binding proteins, this epigenetic modification affects various aspects of … RNA methylation (revisited)
