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Welcome to RNA-Mediated

A Message From J.V.Kohl:

Here you will find information that links physics, chemistry, and molecular epigenetics via RNA-mediated events such as the de novo creation of olfactory receptor genes in order to encourage a public discussion of a paradigm shift.

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Energy-dependent epigenetic translation to mRNA stability (5)

Energy-dependent epigenetic translation to mRNA stability (4) From Fertilization to Adult Sexual Behavior Small intranuclear proteins also participate in generating alternative splicing techniques of pre-mRNA and, by this mechanism, contribute to sexual differentiation in at least two species, Drosophila melanogaster and Caenorhabditis elegans…. See also: The Supraspliceosome – A Multi-Task Machine for Regulated Pre-mRNA Processing in the Cell Nucleus Abstract conclusion: …changes in these regulatory processing activities are associated with human disease and cancer. These findings emphasize the supraspliceosome as…

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Eliminating energy from light induced changes in complex systems

Researchers identify key regulator of fetal growth in mice The study is one of the first to show that KRAB-zinc finger proteins, which are well-known for silencing viral genes left over from ancient infections, can also play an essential role in fetal and placental development. See also: Divergent prebiotic synthesis of pyrimidine and 8-oxo-purine ribonucleotides Conclusion: We have demonstrated the generational relationship between pyrimidine and purine nucleotides by constructing both heterocycles on the same sugar scaffold. The formal (C8)-oxidation level…

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Cytosis in the light of evolution

In the Light of Evolution Excerpt 1 (with my emphasis) Evolutionary Biology bring together a collection of articles exploring how evolutionary principles applied across the spectrum of biology can shed light on a diverse range of topics from molecules to ecosystems, and with a particular emphasis on human genetics, interactions with the environment, and health and disease. Selected research articles will be included in addition to invited reviews and comment. My 2014 invited review of nutritional epigenetics was returned without…

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Energy-dependent epigenetic translation to mRNA stability (4)

See first: Energy-dependent epigenetic translation to mRNA stability (3) First-ever direct observation of chiral currents in quantum Hall atomic simulation The report on the simulation fails to address the facts about what happens at the level of hydrogen-atom transfer in DNA base pairs in solution when you have an MRI. Perhaps the link from chirality to autophagy and all cell type differentiation in all living genera is not obvious.   See: Magnetic resonance imaging MRI is based upon the science…

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Energy-dependent epigenetic translation to mRNA stability (3)

Energy-dependent epigenetic translation to mRNA stability (2) Energy-dependent epigenetic translation to mRNA stability (2) See for comparison this treatise on climate change packaged as information on the evolution of a flying snake. Fossil ‘winged serpent’ is a new species of ancient snake At the time that Zilantophis dwelled there, the site was a sinkhole surrounded by forest, attracting a variety of animals. The local fauna included ancient representatives of familiar North American creatures such as bears, beavers and salamanders. Others…

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Energy-dependent epigenetic translation to mRNA stability (2)

See first: Energy-dependent epigenetic translation to mRNA stability Universe’s ultraviolet background could provide clues about missing galaxies Simulations show that there should be more small galaxies in the Universe, but UV radiation essentially stopped them from developing by depriving them of the gas they need to form stars. UV light constrains the creation of galaxies and also biophysically constrains the creation of the mutations in cancer cells. When will Stephen Hawking and other biologically uninformed theorists admit that their ridiculous…

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Energy-dependent epigenetic translation to mRNA stability

Negative selection in humans and fruit flies involves synergistic epistasis Negative selection against deleterious alleles produced by mutation influences within-population variation as the most pervasive form of natural selection. Naturally occurring positive selection for energy-dependent codon optimality replaced every aspect of neo-Darwinian theories that linked natural selection from mutations to evolution of increasing organismal complexity. Positive selection for epigenetically-effected beneficial alleles links the epigenetic landscape to the physical landscape of supercoiled DNA via nutrient-dependent pheromone-controlled metabolic networks and genetic networks.…

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Ecologically adapted olfaction in humans

Poor human olfaction is a 19th-century myth It is widely believed that the human sense of smell is inferior to that of other mammals, especially rodents and dogs. Reported as: The human sense of smell: It’s stronger than we think May 11, 2017 The energy-dependent de novo creation of G protein-coupled receptors links food odors and pheromones to the biophysically constrained physiology of reproduction in all living genera. Serious scientist have known that all differences in morphological and behavioral phenotypes…

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Collaborating to support ridiculous theories

Outbreaks, Evolution, and Rock ‘n’ Roll: Topol Talks to Pardis Sabeti Dr Topol: You have assembled a global collaborative engine that is exquisite in the real-time sharing of data in these Sherlockian investigations of the mutations in a virus that account for its movement. Through sequencing, we have this remarkable tool. But if not for the fact that you could assemble all of the people and parts around the world, it might not work too well, right? Viruses do not…

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UV light and non-coding RNA

UV Irradiation Induces a Non-coding RNA that Functionally Opposes the Protein Encoded by the Same Gene …these events underlie a switch to expression of short mRNA isoforms and preferential use of alternative last exons in a number of genes, including ASCC3. Intriguingly, the switch between ASCC3 isoforms occurs on more than one level, in that the long mRNA isoform encodes a protein, functioning in the context of the ASCC complex and required for maintaining transcriptional suppression in the late stages of…

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  • What Darwin proved: there’s no such thing as a species
    GENETICS As Animals Mingle, a Baffling Genetic Barrier A short stretch of DNA is challenging what it means to be a species. By: Emily Singer August 5, 2014 Excerpt: “Scientists have dubbed such regions of the genome “islands of speciation.” The persistence of such islands is a phenomenon that has been observed in a variety of […]
  • Do not trust pseudoscientists
    Trust a Scientist: Sex Addiction Is a Myth A psychologist explains why sex addiction therapy is more about faith than facts, as told to Tierney Finster Excerpt 1)  During withdrawal, the brains of addicts create junctions between nerve cells containing...Read more