The eternal significance of microRNAs (9)
(click to enlarge)…many of the viruses infecting us today have ancient evolutionary histories that date back to the first vertebrates and perhaps the first animals in existence.
Viruses do not have evolutionary histories. They adapt to hosts by stealing the quantized energy that is required for fixation of RNA-mediated amino acid substitutions in organized genomes. For example, a report of fixation of one amino acid substitution in the influenza B virus, forced denuclearizaton in North Korea. God-less Communists now live under the threat that their enemies will unleash a variant that was created to decimate their human populations. The fact that the decimation occurs at the level of quantized energy constrained in all cell types can be linked to what others have reported about the significant events in the history of virology.
See: A Single Amino Acid at the Polymerase Acidic Protein Determines the Pathogenicity of Influenza B Viruses and see: Significant Events in the History of Virology
See also: Field-deployable viral diagnostics using CRISPR-Cas13
We developed HUDSON (heating unextracted diagnostic samples to obliterate nucleases), a protocol that pairs with SHERLOCK for viral detection directly from bodily fluids, enabling instrument-free DENV detection… We further demonstrate that SHERLOCK can distinguish the four DENV serotypes, as well as region-specific strains of ZIKV from the 2015–2016 pandemic. Finally, we report … design and testing of instrument-free assays to detect clinically relevant viral single-nucleotide polymorphisms.
Simply put, they have linked testing for one energy-dependent base pair change from one microRNA-mediated amino acid substitution to all virus-driven degradation of messenger RNA in species from bacteria to humans. Senior author Pardis C. Sabeti did this in 2013 with publication of Modeling Recent Human Evolution in Mice by Expression of a Selected EDAR Variant and Identifying Recent Adaptations in Large-Scale Genomic Data.
The mouse-to-human model of food energy-dependent pheromone-controlled ecological adaptations has been detailed in the works published by serious scientists since the time that Bruce McEwen et al., (1964) linked the creation of ATP to the creation of RNA. Dependence of RNA synthesis in isolated thymus nuclei on glycolysis, oxidative carbohydrate catabolism and a type of “oxidative phosphorylation”
The synthesis of RNA in isolated thymus nuclei is ATP dependent.
See also: Positive Natural Selection in the Human Lineage (2006) Pardis C. Sabeti is the first author.
Positive natural selection is the force that drives the increase in prevalence of advantageous traits, and it has played a central role in our development as a species.
Quantized energy-dependent RNA-mediated fixation of amino acid substitutions is the link to the functional structural diversity of supercoiled DNA.
Structural diversity of supercoiled DNA
See also: All About that Base (Meghan Trainor Parody) 12/10/14
