Silencing genes — to understand them

Excerpt: “RNAi and other processes may help science understand how life works at the most basic level.”

My comment: Serious scientists already understand how life works at the most basic level.  Viral microRNAs perturb protein folding that links nutrient-dependent microRNAs to DNA repair via the conserved molecular mechanisms that link amino acid substitutions to the biophysically constrained chemistry of protein folding, which is required for genomic stability and increasing organismal complexity.

Fixation of the amino acid substitutions occurs via the nutrient-dependent physiology of reproduction. The physiology of nutrient-dependent reproduction links the light-induced de novo creation of amino acids to RNA-mediated events and cell type differentiation in all cells of all individuals of all genera. The balance of viral microRNAs and nutrient-dependent microRNAs is the key to increasing organismal complexity and physiopathology.

Without mentioning microRNAs, this article refers to them as ‘triggering molecules’ that contain a string of 21 or 22 nucleotides. For comparison, see: MicroRNA control of protein expression noise.

Theoretical physicists and evolutionary theorists seem to consistently ignore the established links from the epigenetic landscape to the physical landscape of DNA in the organized genomes of species from microbes to man.  They are foolish if they think serious scientists will continue to ignore the role of microRNAs that link physics to chemistry and molecular biology. Serious scientists have had enough of pseudoscientific nonsense. Theorists explain nothing, but see:

This explains everything

Excerpt: “If scientists cannot communicate a concept without falling back on maths, they don’t truly grasp what it is they are trying to talk about. It is a failure of the communicator, not of the audience.

My comment: It is the failure to communicate without using maths that led to acceptance of the assumptions of population geneticists and their idiot minions. They based their ridiculous theories on de Vries definition of mutation and ideas about how long it would take an accumulation of mutations to lead to a new species. Their theories led to the stagnation of research that finally links microRNAs to cell type differentiation via the biophysically constrained chemistry of nutrient-dependent RNA-mediated protein folding and fixation of amino acid substitutions via the physiology of reproduction.

Weinberg, and others like him, think that maths can explain top-down causation in the context of biology and the controlled physiology of reproduction. They explain nothing and tout only pseudoscientific nonsense. For contrast, see:

1996  “Small intranuclear proteins also participate in generating alternative splicing techniques of pre-mRNA and, by this mechanism, contribute to sexual differentiation in at least two species, Drosophila melanogaster and Caenorhabditis elegans…”

2003 “First, more sophisticated models of nonsynonymous evolution are required, specifically those that allow a limited number of sites to accumulate the vast majority of changes, as may be true of viruses in nature, as well as those that take account of RNA and protein secondary structure (15).”

New target for anticancer drugs—RNA

Excerpt 1 with my emphasis) “Our new results indicate that a number of key cancer-causing genes – genes that under normal circumstances keep cells under control – are held in check before the proteins are made,” Cate said. “This new control step, which no one knew about before, could be a great target for new anticancer drugs.
Excerpt 2) While our genes reside inside the cell’s nucleus, the machinery for making proteins is in the cytoplasm, and mRNA is the messenger between the two. All the DNA of a gene is transcribed into RNA, after which nonfunctional pieces are snipped out to produce mRNA. The mRNA is then shuttled out of the nucleus to the cytoplasm, where a so-called initiation complex gloms onto mRNA and escorts it to the ribosome. The ribosome reads the sequence of nucleic acids in the mRNA and spits out a sequence of amino acids: a protein.

My comment: What they claim is a new control step is the balance of viral microRNAs to nutrient-dependent microRNAs controls cell type differentiation via RNA-directed DNA methylation and RNA-mediated amino acid substitutions. Misrepresenting the control of cell type differentiation by RNA as a “…new control step, which no one knew about before…” is a continuation of the nonsense that keeps funding directed to those who deny what has been known about cell type differentiation for nearly two decades.

Clinically Actionable Genotypes Among 10,000 Patients With Preemptive Pharmacogenomic Testing establishes the obvious links between RNA-mediated metabolic networks and genetic networks.

Oppositional COMT Val158Met effects on resting state functional connectivity in adolescents and adults places what is known about cell type differentiation into the context of a single amino acid substitution that affects RNA-mediated metabolic networks; RNA-mediated genetic networks; and human behavior.

Stop the nonsense. Serious scientists are Combating Evolution to Fight Disease.

Pseudoscientists are telling you there is a “…new control step, which no one knew about before…” to get funding for anticancer drugs by ignoring what has been known for decades about RNA-mediated amino acid substitutions and cell type differentiation.

Dobzhansky (1973) “…the so-called alpha chains of hemoglobin have identical sequences of amino acids in man and the chimpanzee, but they differ in a single amino acid (out of 141) in the gorilla” (p. 127).

 

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