Watch what happens after the folks at “Complex Biological Systems Alliance” and George Ellis have realized the seriousness of their failure to link the sun’s biological energy from top-down causation in an atoms to ecosystems model of how metabolic networks and genetic networks are linked to the supercoiled DNA that protects organized genomes from virus driven genomic entropy.
“Complex Biological Systems Alliance” and George Ellis both recently reported this news from last year, after I mentioned it again on my FB group and here at RNA-mediated.com
My comment: All neo-Darwinian pseudoscientific nonsense now must be addressed by every other theorist who thought that mutations explained how evolution occurs, despite repeated claims that nutrient-dependent cell type differentiation must be the first consideration.
Complex Biological Systems Alliance reported this on October 4, 2015 as:
Our research was recently published in Science.
“Somatic mutation in human neurons single transcriptional developmental history and tracks.”
The study is featured on the cover of the October 2nd 2015 issue.
“Neurons live for Decades in a postmitotic state, Their genomes susceptible to DNA damage. Here we survey the landscape of somatic single-nucleotide variants (SNVs) Identified in the human brain.We Thousands of somatic SNVs by single-cell sequencing of 36 neurons from the cerebral cortex of three Normal Individuals. UNLIKE SNVs germline and cancer, Which are Often Caused by errors in DNA replication, mutations neuronal Appear During Reflect Damage to activate transcription. Somatic mutations create nested lineage trees, dated Allowing them to be relative to developmental revealing a polyclonal landmarks and architecture of the human cerebral cortex. THUS, somatic mutations in the brain Represent a durable and ongoing record of neuronal life history, from Development through postmitotic function. ”
Our statistical model indicates that mutagenesis is a non-random process. These findings have far-reaching implications in biology and medicine.
My comment: The fact that mutagenesis is a non-random process limits any further attempts by neo-Darwinian theorists to link mutations to evolution. Mutations can be linked to pathology, but not to healthy longevity and biodiversity via biophysically constrained RNA-mediated protein folding chemistry.
from June 15, 2015 was reported by Complex Biological Systems Alliance on November 13, 2015
from November 12, 2015 was reported via a link from Complex Biological Systems Alliance on November 13, 2015
from November 4, 2015 was reported via a link from Complex Biological Systems Alliance on November 4, 2015
Everything reported by the Complex Biological Systems Alliance in the four articles linked above can be placed into the context of what I reported more than a year ago, on October 15, 2014
The strong connection between quantum physics and structural biology means that light harvesting functions are not under genetic and evolutionary control. The connection from physics to biology links the epigenetic landscape to the physical landscape of DNA in the organized genomes of plants and animals via the conserved molecular mechanisms of amino acid substitutions and controlled protein folding that leads from ecological variation to ecological adaptations.
My comment: It should not be much longer until the Complex Biological Systems Alliance realizes that the anti-entropic energy of the sun is linked to nutrient energy-dependent healthy longevity. At the same time they may realize that viruses steal that energy, which makes it appear that cancer cells hijack glucose.
Viruses hijack the energy that link thermodynamic cycles of protein biosynthesis and degradation from RNA-mediated cell type differentiation to biodiversity via biophysically constrained molecular mechanisms we reported in the context of our section on molecular epigenetics in our 1996 Hormones and Behavior review: From Fertilization to Adult Sexual Behavior.
I will be interesting to see how long it takes Complex Biological Systems Alliance to realize what we detailed nearly 20 years ago, and apply it to what they are reporting in the context of non-random mutagenesis and “evolution.” They are reporting links between ecological variation and ecological adaptation, but seem to not realize how cell type differentiation occurs in species from microbes to humans.
1) …a core cancer phenotype is activated to varying degrees across diverse tumor types.
2) …pan-cancer studies of transcriptional changes have focused mainly on tumor samples, without consideration of normal tissue.
3) …a pan-cancer analysis of differential transcriptional regulatory programs—whether at the level of mRNA expression, miRNA expression or methylation—has not yet been performed.
My comment: Evolutionary theorists are pseudoscientists who do not know how cell type differentiation occurs. They steal the funding from serious scientists. That funding would already have led to the required pan-cancer analysis of differential transcriptional regulatory programs. That analysis will differentiate between nutrient-dependent organization of healthy genomes and virus perturbed genomic entropy. The analysis need only compare the number of viral microRNAs to the number of nutrient-dependent microRNAs in normal tissue to cancerous cell types in different tissues.
Predictably, all the cancerous tissues will have more viral microRNAs than nutrient-dependent microRNAs. That prediction is readily made by any serious scientist who understands how atoms and ecosystems must be linked to biophysically constrained RNA-mediated protein folding chemistry in all genera via the physiology of reproduction. The nutrient-dependent biophysically constrained physiology of reproduction links the innate immune system of all individuals of all species to the supercoiled DNA that protects their organized genomes from virus-driven entropy.