Chromosomal rearrangements reported as genomic rearrangements (2014)

By: James V. Kohl | Published on: June 19, 2018

The Architecture of a Scrambled Genome Reveals Massive Levels of Genomic Rearrangement during Development

Genome-wide DNA rearrangements are most exaggerated in ciliates, particularly in the model organism Oxytricha trifallax, which programs not only DNA deletion, but also total reorganization, through RNA-mediated events (Fang et al., 2012; Nowacki et al., 2008).

Reported as: In one of nature’s innovations, a single cell smashes and rebuilds its own genome

Previous work in Landweber’s lab—a 2012 publication in Cell and a 2008 paper in the journal Nature—showed that millions of noncoding RNA molecules from the previous generation direct this undertaking by marking and sorting the DNA pieces in the correct order.

See my comments to the physorg.com site.

For example:

“…millions of noncoding RNA molecules from the previous generation direct this undertaking by marking and sorting the DNA pieces in the correct order.”

Are the millions of noncoding RNA molecules from the previous generation nutrient-dependent. Do they facilitate transgenerational epigenetic inheritance via pheromone-controlled reproduction? Is this another example of how evolutionary theorists have ignored the epigenetic link from ecological variation to amino acid substitutions that differentiate cell types, which are linked to ecological adaptations via chromosomal rearrangements instead of mutations and natural selection?

How could it not be? See: Nutrient-dependent/pheromone-controlled adaptive evolution: a model.

Moving forward from 2013 and 2014.

MinION USB stick gene sequencer finally comes to market

  • By John Hewitt on September 19, 2014 at 2:10 pm

A final, cutting-edge new example highlights just how far some cells, and creatures, go to reconfigure their original “genome” throughout their lives. Every time a bizarre organism known as Oxytricha trifallax has a sexual encounter, it decrypts its own DNA and builds an entirely new version together with its partner. Strangely, there is no actual reproduction involved in these encounters, just exchange of DNA. Such extreme genetic rewiring is now just beginning to be witnessed, much less understood.

 John Hewitt has done the unthinkable. He linked starvation in single-celled organisms with sexually differentiated cell types to RNA-mediated chromosomal rearrangements in humans via an accurate portrayal of what is known about the technology of human genome sequencing.  Conserved molecular mechanisms that link the epigenetic landscape to the physical landscape of DNA in the organized genomes of all species. Hewitt’s report shows what happens to evolutionary theory when biological facts are presented that link microbes to man. Simply put, theories that link mutations to the evolution of biodiversity are refuted by the fact that nutrient-dependent RNA-directed DNA methylation and amino acid substitutions link chromosomal rearrangements via the control of reproduction via species-specific pheromones. The pheromones are metabolites of nutrients, which means that the physiology of reproduction is controlled by nutrient uptake which leads to amino acid substitutions that are fixed in the genomes of all species via their reproduction, not via mutations, natural selection or any other theoretical explanation touted by evolutionary theorists.

Previous work in Landweber’s lab—a 2012 publication in Cell and a 2008 paper in the journal Nature—showed that millions of noncoding RNA molecules from the previous generation direct this undertaking by marking and sorting the DNA pieces in the correct order.Read more at: https://phys.org/news/2014-09-nature-cell-rebuilds-genome.html#jCp

Previous work in Landweber’s lab—a 2012 publication in Cell and a 2008 paper in the journal Nature—showed that millions of noncoding RNA molecules from the previous generation direct this undertaking by marking and sorting the DNA pieces in the correct order.Read more at: https://phys.org/news/2014-09-nature-cell-rebuilds-genome.html#jCp
Previous work in Landweber’s lab—a 2012 publication in Cell and a 2008 paper in the journal Nature—showed that millions of noncoding RNA molecules from the previous generation direct this undertaking by marking and sorting the DNA pieces in the correct order.Read more at: https://phys.org/news/2014-09-nature-cell-rebuilds-genome.html#jCp

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